This $114,976 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support research conducted by Seattle Children's Research Institute to elucidate the function of T cells present in breastmilk and their potential role in protecting infants against respiratory infections. The key objectives are to: 1) investigate the transcriptional and clonal overlap between T cells in the lactating breast and upper...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $534,418 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Georgia Research Foundation, Inc. The five-year grant, awarded on August 1, 2025, will investigate how components of human breastmilk can suppress the survival of the pathogenic bacterium Campylobacter jejuni, a major cause of diarrheal disease worldwide. The project aims to identify the specific...
This Project Grant award, valued at $242,310.00, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The grant supports research conducted by Weill Medical College of Cornell University to investigate how the early-life intestinal microbiome and maternal antibodies influence the trafficking of commensal microbes to the thymus, which is critical for the development of the...
This $2,654,646 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports a multi-year program to better understand the unique characteristics of the human immune response in early life. The program aims to uncover genetic and developmental determinants of pediatric immunity, examine how immune parameters evolve over childhood, and elucidate how baseline immune states predict responses to...
This federal Project Grant award of $508,500.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports a study titled "BREATH - Breastfeeding, Early-Life Microbiome and Respiratory Health Study" at New York University School of Medicine. The research aims to elucidate the intricate relationships between breastfeeding, infant microbiome development, and early-life respiratory health...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,336,490 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Sloan-Kettering Institute for Cancer Research in New York, NY. The 5-year grant, awarded on August 6, 2024, supports research to understand B cell and antibody responses to placental versus foreign antigens, with the goal of illuminating how dysregulated responses contribute to pregnancy complications and informing...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,999,774 to the Regents of the University of Minnesota to conduct research focused on understanding how maternal microbial exposure fundamentally shapes the CD8 T cell population at the maternal-fetal interface. The key objectives are to investigate the regulation of CD8 T cell tolerance and host immune defense...
This $797,735 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to elucidate the cellular and molecular mechanisms governing heightened immune responses in neonates. The research project will utilize a novel mouse model to investigate how the innate immune system detects and mediates sterile inflammation during early life development, with the goal of developing targeted...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,112,004 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant, effective September 1, 2024 through July 31, 2029, will support research to define the mechanistic features of Interleukin-27 (IL-27) signaling at the maternal-fetal interface that...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $3,194,992 to the University of California, San Diego (UC San Diego) to conduct research on the roles and regulation of tissue-resident CD8 T cells during a persistent viral infection. The key objectives are to: (1) evaluate the role of tissue-resident CD8 T cells in intestinal hyper-permeability and colitis during a sustained viral...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $562,500.00 to The Salk Institute for Biological Studies to investigate the functions of specialized intestinal T cells, called intraepithelial lymphocytes (IELs), that are recruited to the mammary gland during lactogenesis. The goal is to understand how these entero-mammary IELs promote maternal-offspring immunity by regulating milk-producing mammary epithelial cells and shaping milk composition. The award period runs from July 23, 2025 to June 30, 2030. This research aims to establish the role of entero-mammary IELs in lactogenesis and uncover the mechanisms by which these cells regulate mammary epithelial cells, leading to insights that could enhance maternal immunity, improve breastfeeding outcomes, and boost offspring health in early life.