Project Grant R21AI182901

Award Date 7/9/24
Completion Date 5/31/26
Dollars Obligated $564K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
New York, NY 10065, USA
Similar Awards
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $193,644 to The Trustees of Columbia University in the City of New York to conduct research on the impact of immune imprinting from prior SARS-CoV-2 variant exposure on antibody responses to emerging variants. The key objectives are to: 1) Test the effect of immune imprinting on neutralizing antibody responses in a...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) provides $190,058 to the University of Massachusetts Medical School to investigate the role of the ADAM9 protein in the immune response to SARS-CoV-2 infection. The goal is to define how ADAM9 impacts the immunopathogenesis of severe COVID-19 and its effects on acute lung injury. The research will build on the grantee's preliminary findings...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $631,977 Project Grant (CFDA 93.855 Allergy and Infectious Diseases Research) to Weill Medical College of Cornell University to conduct research aimed at enhancing immunological memory and reducing the burden of infectious diseases. The research will focus on understanding how caloric restriction induces metabolic reprogramming in memory CD8+ T cells to increase interferon production, which combines with...
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a $781,367 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Weill Medical College of Cornell University. The grant, awarded on January 25, 2024, will support research to define and maximize the impact of CD8+ T-cell selection on the landscape of HIV integration sites. The goal is to optimize strategies for eradicating the persistent reservoir of HIV-infected cells and achieve...
This Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research will support research to investigate the mechanisms driving Long COVID (LC) pathology and identify potential therapeutic targets. The $175,428 award will fund a 2-year study at the University of Pennsylvania focused on leveraging SARS-CoV-2-, Epstein-Barr virus (EBV)-, and varicella zoster virus (VZV)-specific T cells to better understand...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $147,486.00 to the Icahn School of Medicine at Mount Sinai to conduct high-resolution immunological characterizations of a novel murine model of chronic hepacivirus infection. The goal is to study the evolution of immune dysfunction over the course of infection and better understand the molecular drivers of T cell exhaustion and viral...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $148,824 to the Research Foundation of the City University of New York (RFCUNY) over a 5-year period from August 2024 to July 2029. The goal of the research is to understand the clinical and social factors that impact HIV and COVID-19 outcomes among people with HIV (PWH), and to characterize how the COVID-19...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $188,544 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Iowa. The grant will fund research to better understand the molecular mechanisms underlying SARS-CoV-2 infection and innate immune regulation. Specifically, the project aims to examine the role of the protein SAMHD1 in regulating SARS-CoV-2-induced inflammation in primary human airway epithelial cell...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $814,873 to conduct research on the immunogenetics of the COVID-19 immune response. The key objectives are to: Perform a large genome-wide association study to identify genetic associations with COVID-19 infection and vaccine-induced immune responses, including antibody levels. This includes replicating findings in...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is supporting research to investigate the role of T cells in promoting post-acute memory deficits after COVID-19 infection in mice. The $107,995 award to The Washington University, which runs from July 2025 to June 2027, will fund a study to determine how pathogenic CD4+ T cells are recruited to the central nervous...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $563,588 to Weill Medical College of Cornell University to study the effects of immunosuppression on SARS-CoV-2 persistence, virus genetic diversity, and clinical outcomes of COVID-19. The research aims to determine the immune defects linked to prolonged SARS-CoV-2 replication in immunocompromised hosts, and ascertain the effect of different immunosuppressive conditions and therapies on viral genetic diversity. The findings are expected to advance the understanding of immune mechanisms involved in SARS-CoV-2 persistence in immunocompromised individuals and inform the development of optimal therapies and public health interventions to prevent the emergence and spread of new viral variants. The award period is from July 2024 to May 2026.

Generated 7/1/25, 2:05 AM