This Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 - Allergy and Infectious Diseases Research will support research to investigate the mechanisms driving Long COVID (LC) pathology and identify potential therapeutic targets. The $175,428 award will fund a 2-year study at the University of Pennsylvania focused on leveraging SARS-CoV-2-, Epstein-Barr virus (EBV)-, and varicella zoster virus (VZV)-specific T cells to better understand...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $3,659,973 to the University of South Florida to investigate the molecular mechanisms underlying neurological sequelae, known as "Neuro-COVID", associated with SARS-CoV-2 (COVID-19) infection, with a focus on tau-based neurodegeneration and the impact of aging. The research aims to: 1) Assess how COVID-19 infection exacerbates age-related inflammation and tauopathy,...
This federal Project Grant award of $705,557 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to better understand the coordination of innate and cellular mucosal immunity in SARS-CoV-2 clearance. The primary objectives are to determine the contribution of monocytes in promoting T cell responses and viral control within the respiratory tract, and to define the effector mechanisms of...
This Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) provides $600,000 to Rush University Medical Center to investigate the role of antibodies in the neurological effects of COVID-19. The key objectives are to: 1) elucidate the impact of inflammatory antibodies on brain cells and endothelial cells; 2) examine the trafficking and effects of inflammatory and anti-inflammatory antibodies in a chimeric human brain mouse...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to investigate the mechanisms by which SARS-CoV-2 infection causes neurological damage, leading to a syndrome known as Post-Acute Sequelae of COVID-19 (PASC) or "NeuroPASC". The total award amount is $634,622.00 over the project period from December 1, 2024 to November 30,...
This Cooperative Agreement award for $2,380,350 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research at Washington University to study the mechanisms of broadly protective immune responses against respiratory viruses, including SARS-CoV-2 and influenza. The two main goals are: (A) defining the mechanisms of germinal center persistence after vaccination and how that impacts long-lived...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $380,320 to the Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, to conduct research on elucidating the lineage dynamics of optimal human CD8 T cell responses to SARS-CoV-2 and how CD8 T cell homeostasis is altered in Long COVID. The research aims to define human memory...
This $1,120,805 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), will support research to investigate how prior SARS-CoV-2 infection may increase the risk of vascular contributions to cognitive impairment and dementia (VCID). The research aims to: Determine how prior SARS-CoV-2 infection influences blood-brain barrier...
The federal Project Grant award of $654,367.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant, awarded on January 1, 2025, supports research to investigate the neural mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 (PASC), also known as "Long COVID". The research aims to determine the relationship...
This federal Project Grant award of $192,888 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to evaluate the generation, differentiation, breadth, and persistence of SARS-CoV-2-specific CD4+ and CD8+ T cell responses in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) patients after vaccination and infection. The goal is to provide in-depth knowledge of...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is supporting research to investigate the role of T cells in promoting post-acute memory deficits after COVID-19 infection in mice. The $107,995 award to The Washington University, which runs from July 2025 to June 2027, will fund a study to determine how pathogenic CD4+ T cells are recruited to the central nervous system after SARS-CoV-2 infection and how they contribute to persistent learning and memory deficits. The research aims to elucidate fundamental mechanisms by which the immune response to viral infections can impact neurological function, with the potential to identify targets for treating the neurological symptoms of post-acute sequelae of SARS-CoV-2 (PASC).