This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $318,085 to support research on the role of antibodies in controlling virus infections through Fc-dependent mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytolysis (CDC). The research aims to elucidate the...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $489,500 to support structural studies of the full-length nucleocapsid (N) protein of SARS-CoV-2. The goal is to determine the high-resolution structure of the full-length N protein in complex with the viral RNA using cryogenic electron microscopy. This research aims to advance the understanding of the...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $188,544 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The University of Iowa. The grant will fund research to better understand the molecular mechanisms underlying SARS-CoV-2 infection and innate immune regulation. Specifically, the project aims to examine the role of the protein SAMHD1 in regulating SARS-CoV-2-induced inflammation in primary human airway epithelial cell...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $243,713.00 to the University of Massachusetts Medical School to conduct comprehensive research on the evolution of drug resistance in SARS-CoV-2. The project aims to systematically investigate the interdependence of mutations that disrupt drug binding and those that increase enzyme activity, which are typically...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $578,093 to the University of Massachusetts Medical School to conduct research on a novel human damage-associated molecular pattern (DAMP) receptor, its murine counterpart, and their ligand, GAPDH. The research aims to elucidate the structure, function, and pathophysiology of this DAMP receptor system in both humans...
This Project Grant award of $217,337 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to elucidate the role of the SARS-CoV-2 ORF9B protein in virus replication. The research aims to investigate the impact of ORF9B phosphorylation on SARS-CoV-2 replication and generate a detailed interaction map of ORF9B during infection, in order to provide significant insights into the biological...
This federal Project Grant award of $705,557 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to better understand the coordination of innate and cellular mucosal immunity in SARS-CoV-2 clearance. The primary objectives are to determine the contribution of monocytes in promoting T cell responses and viral control within the respiratory tract, and to define the effector mechanisms of...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $437,895 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to The Research Foundation For The State University Of New York (RF SUNY) to investigate the role of the 90K protein in SARS-CoV-2 infection. The key objectives are to provide mechanistic evidence on the effect of 90K during SARS-CoV-2 infection and to identify how SARS-CoV-2 accessory proteins may counteract 90K's antiviral activity. This...
This Project Grant award of $582,618.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855). The grant supports research to determine the mechanisms by which RNA N6-methyladenosine (m6A) and pseudouridine (Ψ) modifications modulate SARS-CoV-2 replication, gene expression, immunity, and pathogenesis. Key activities include using CRISPR-Cas9 to knock out host RNA...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) provides $1,172,336.00 to the University of Massachusetts Medical School over a 5-year period starting on August 19, 2024. The goal of the research is to investigate how distinct age-associated B cell subsets can protect the aged from influenza. Specifically, the project will determine the potential of different...