The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Texas Biomedical Research Institute, doing business as Southwest Foundation For Biomedical Research, to support research on "Mechanisms of Efficient Control of Mycobacterium Tuberculosis in the Lungs Prior to Granuloma." The $1,091,124 grant, with a project period from Jul 9, 2024 to May 31, 2029, will fund the use of cutting-edge techniques such as single cell RNA sequencing, PET/CT scans, and single cell imaging to understand the immune responses generated by an attenuated, live-replicating Mycobacterium tuberculosis (MTB) strain and its potential as a vaccine candidate. The research aims to identify mechanisms by which MTB infection can be sterilized prior to the formation of the granuloma. The project includes a $271,620 sub-award to the University of Chicago to support related research activities.
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