Project Grant R21AG104493
- The National Institute on Aging, within the Department of Health and Human Services, awarded The Medical College of Wisconsin, Inc. $429,000 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how overexpression of human chromosome 21 (HSA21) orthologs affects neurodegeneration during aging in Caenorhabditis elegans. The project addresses variability in dementia onset among individuals with Down syndrome, which results from trisomy 21. While approximately 75...
- The National Institute on Aging at the Department of Health and Human Services awarded $429,262 to The Research Foundation For The State University of New York (Stony Brook University) on February 1, 2026, under the Aging Research program (CFDA 93.866, Assistance Listing Project Grant R21AG093544). The award funds research into ciliopathy features in mouse models of Down syndrome. The project examines how trisomy 21 disrupts ciliary function in the brain's ventricular system, which is critical...
- The National Institutes of Health Office of the Director awarded $2.693 million to the University of Wisconsin–Madison on September 15, 2025, under the Trans-NIH Research Support program (CFDA 93.310) to establish an Alzheimer's disease biomarker clock in Down syndrome using positron emission tomography and plasma analytes. The research addresses the underrepresentation of individuals with Down syndrome in Alzheimer's disease therapeutic trials by characterizing biomarker progression in this...
- The National Institute on Aging awarded the University of Massachusetts Medical School $452,783 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop genetically encoded intrabodies that inhibit individual enzymatic domains of retrotransposons in order to define retrotransposon function in synaptic development. The project addresses a critical gap in functional genomics: traditional loss-of-function approaches such as gene knockout and RNA interference cannot decouple...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded the University of Wisconsin System $568,615 on September 2, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the molecular mechanisms underlying synaptic deficiency in Down syndrome. The research project, titled "Molecular Mechanisms Underlying Synaptic Deficiency in Down Syndrome" (R01HD120347), will use isogenic trisomy 21 disorder-specific human...
- The National Institute on Aging awarded the University of Wisconsin–Madison $427,625 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of the molecular chaperone BAG6 as a potential suppressor of neurodegeneration in cellular and mouse models of ubiquilin-2 (UBQLN2)-associated amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). This is an exploratory R21 project grant (R21AG098513). The research will define how BAG6–UBQLN2...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Thomas Jefferson University $429,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to characterize neurodegenerative hallmarks in induced neural stem cells (iNSCs) derived from patient fibroblasts to study dsRNA-mediated inflammation in C9ORF72-associated ALS and frontotemporal dementia. The research employs a novel disease model using age-preserved iNSCs directly...
- Federal Grant Award Summary Oregon Health & Science University received a $780,000 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective June 15, 2025, through May 31, 2027. The award funds research investigating allelic expression imbalance in trisomy 21 (Down syndrome), with particular emphasis on understanding epigenetic mechanisms that regulate dosage-sensitive genes on chromosome 21. The research examines how epigenetic...
- The National Institute on Aging awarded the University of Wisconsin-Madison $427,625 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate cerebral small vessel disease pathways in vascular contributions to cognitive impairment and dementia and Alzheimer's disease using ferumoxytol-enhanced MRI. The research will employ novel microvascular biomarkers including quantitative characterization of vascular density and hemodynamic measures of microvascular pulsatility...
- The National Institute on Aging awarded The Washington University $406,707 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to conduct a national longitudinal study examining whether integrated dual-eligible special needs plans improve health outcomes for adults with intellectual disabilities and dementia who are dually enrolled in Medicare and Medicaid. The study addresses the absence of national research on dementia care access, quality, and outcomes among...
The National Institute on Aging awarded the University of Wisconsin – Madison $424,648 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate ribosome quality control defects in trisomy 21 aging. The project tests a novel hypothesis that premature aging and cellular stress in Down syndrome cells arise from defects in translational fidelity and ribosome quality control caused by chromosome amplification, rather than from specific genes on chromosome 21. The research uses an induced pluripotent stem cell model with isogenic pairs of trisomy 21 and euploid cell lines to dissect the consequences of trisomy 21 independent of personal genetic variation. The work focuses on neural progenitor cells and will examine protein aggregation, ubiquitin distribution defects, cell-cycle control aberrations, and metabolic dysfunction observed in premature aging and early-onset Alzheimer's disease associated with Down syndrome. Performance occurs at the University of Wisconsin – Madison, Madison, Wisconsin. The period of performance runs from September 1, 2026, through August 31, 2028. This is a Project Grant, a form of assistance funding under the National Institute on Aging's mission to support biomedical and behavioral research directed toward understanding aging and preventing Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $424.6k | 8/27/26 |