Project Grant R21AG098616
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $312,000 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 1, 2025, through May 31, 2027. The research project investigates the functional role of late-onset Alzheimer's disease (LOAD)-associated genes in neurodegeneration and protein aggregation-induced neurotoxicity. Using Caenorhabditis elegans as a model organism, the research aims to...
- Federal Project Grant Award Summary The National Institute on Aging awarded The Medical College of Wisconsin, Inc. a Project Grant totaling $441,460 under the Aging Research program (CFDA 93.866) for the period February 1, 2026 through January 31, 2028. This research initiative investigates the role of the adaptor protein P66SHC in cerebrovascular dysfunction associated with Alzheimer's disease and related dementias. The research aims to elucidate molecular mechanisms linking vascular impairment...
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $780,000 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 15, 2025, with completion targeted for May 31, 2027. The research project investigates allelic expression imbalance in Trisomy 21 (Down syndrome), focusing on epigenetic regulation mechanisms at dosage-sensitive genes on chromosome 21. Specifically, the research aims to elucidate...
- Federal Project Grant Award Summary The National Institutes of Health (NIH) Office of the Director awarded $2,693,746 under the Trans-NIH Research Support program (CFDA 93.310) to the University of Wisconsin-Madison on September 15, 2025, for a project extending through August 31, 2029. The project, "Establishing an Alzheimer's Disease Biomarker Clock in Down Syndrome Using Positron Emission Tomography and Plasma Analytes," will develop research products and methodologies to advance...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $445,130 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. This research project focuses on elucidating the mechanisms by which Membrane Spanning 4A (MS4A) genes regulate neurodegeneration in Alzheimer's disease and related neurodegenerative disorders, including frontotemporal dementia,...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant totaling $1,851,569 under the Aging Research program (CFDA 93.866) for the period June 1, 2025, through March 31, 2030. This research initiative, titled "First In Last Out: How Development Informs Neurodegeneration," investigates the biological mechanisms linking early brain development to late-life Alzheimer's disease (AD) pathology. The project aims to empirically...
- Federal Grant Award Summary The National Institute on Aging awarded Stony Brook University a Project Grant of $429,262 under the Aging Research program (CFDA 93.866) for research investigating ciliopathy features in mouse models of Down syndrome. The award period runs from February 1, 2026, through January 31, 2028. The research team will develop and apply novel techniques for live imaging and computational analysis of ciliated ependymal cells lining brain ventricles, including automated...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Tufts University School of Medicine a $470,000 Project Grant under the Aging Research program (CFDA 93.866) on February 1, 2026, with a completion date of January 31, 2028. This grant funds research titled "Elucidating the Interplay Between AD Genetic Variants Using Human iPSC-Derived Brain Cells," which investigates the genetic mechanisms underlying Alzheimer's disease (AD). Given that AD has an estimated...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded University of Wisconsin-Madison a $640,906 Project Grant effective June 1, 2025, through March 31, 2030, under the Aging Research program (CFDA 93.866). The project delivers advanced neuroimaging research and analysis services focused on elucidating cerebrovascular disease (CVD) pathways to cognitive decline. The primary products include the development and application of a suite of non-invasive vascular neuroimaging tools...
- Federal Project Grant Award Summary Duke University's Office of Research Administration is executing a scientific research project funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The $715,801 project grant, awarded June 1, 2025, with completion scheduled for March 31, 2030, supports biomedical research investigating the mechanisms linking hypertension and aging to postoperative delirium and subsequent Alzheimer's disease and related dementias...
The Medical College of Wisconsin, Inc. received a $429,000 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 1, 2026, with completion by January 31, 2028. The research project investigates the role of chromosome 21 (HSA21) gene overexpression in aging-associated and amyloid-beta-induced neurodegeneration using Caenorhabditis elegans as a model organism. The primary deliverable is a systematic genetic and functional investigation combining genetics, cell biology, biochemistry, and behavioral analysis to identify HSA21 gene orthologs—beyond the well-characterized APP gene—that contribute to neurodegeneration risk and dementia progression in Down syndrome and Alzheimer's disease-related pathology. This research addresses a critical knowledge gap regarding the variability in dementia onset among Down syndrome individuals by mapping over 50 conserved HSA21 gene orthologs in C. elegans to aging-related neuronal phenotypes. The project outcomes will provide foundational data identifying genetic factors beyond APP that influence neurodegeneration during aging, potentially enabling earlier interventions and improved understanding of Down syndrome-associated Alzheimer's disease pathogenesis. Deliverables include experimental findings, genetic and behavioral datasets, and published research advancing understanding of age-related neurodegeneration mechanisms.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.0k | 1/29/26 |