Project Grant R21AG093544
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $780,000 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 15, 2025, with completion targeted for May 31, 2027. The research project investigates allelic expression imbalance in Trisomy 21 (Down syndrome), focusing on epigenetic regulation mechanisms at dosage-sensitive genes on chromosome 21. Specifically, the research aims to elucidate...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded $372,904 to The University of Texas Health Science Center at San Antonio under the Aging Research program (CFDA 93.866) on September 20, 2025, for a project period extending through May 31, 2030. This R25 training grant delivers annual advanced hands-on clinical research laboratory courses focused on Down Syndrome (DS) across the lifespan, recruiting and training 16 post-graduate participants annually in DS clinical...
- This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $2,357,335 to study neuronal dysfunction in Down syndrome (DS) and its link to Alzheimer's disease (AD). The key products and services delivered under this award include: Utilizing induced pluripotent stem cell (iPSC)-derived cortical organoids and assembloids to examine the cellular, transcriptomic, and motility-related...
- Federal Grant Award Summary The University of Kansas Medical Center Research Institute, Inc. received a $155,504 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective March 1, 2026, with a completion date of September 7, 2027. This research project investigates the associations between body composition, moderate-to-vigorous physical activity (MVPA), and cognitive function in adults with Down syndrome (DS). The project addresses a...
- Federal Project Grant Award Summary The Medical College of Wisconsin, Inc. received a $429,000 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 1, 2026, with completion by January 31, 2028. The research project investigates the role of chromosome 21 (HSA21) gene overexpression in aging-associated and amyloid-beta-induced neurodegeneration using Caenorhabditis elegans as a model organism. The primary deliverable is a systematic genetic...
- Federal Grant Award Summary J. David Gladstone Institutes received a $1.46 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) to conduct research on inhibitory neuron dysfunction in Alzheimer's disease models. The award, effective August 1, 2025 through July 31, 2027, supports the development and implementation of innovative methodologies to monitor and manipulate parvalbumin (PVALB) and somatostatin (SST) inhibitory interneuron...
- Federal Project Grant Award Summary Icahn School of Medicine at Mount Sinai received a $1,257,163 Project Grant from the National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective July 1, 2025 through June 30, 2030. The award supports research investigating the role of follicle-stimulating hormone (FSH) in Alzheimer's disease pathology and co-occurring health conditions in individuals with Down syndrome. The research will measure...
- Federal Project Grant Award Summary Duke University's Office of Research Administration is executing a scientific research project funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The $715,801 project grant, awarded June 1, 2025, with completion scheduled for March 31, 2030, supports biomedical research investigating the mechanisms linking hypertension and aging to postoperative delirium and subsequent Alzheimer's disease and related dementias...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Feinstein Institutes for Medical Research a $2.44M project grant under the Aging Research program (CFDA 93.866) effective June 15, 2025, through February 28, 2030. This prospective observational cohort study will evaluate and predict oropharyngeal dysphagia (OD) improvement in hospitalized patients with Alzheimer's disease and related dementias (AD/ADRD). The research addresses a critical clinical gap wherein dysphagia...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Tufts University School of Medicine a $470,000 Project Grant under the Aging Research program (CFDA 93.866) on February 1, 2026, with a completion date of January 31, 2028. This grant funds research titled "Elucidating the Interplay Between AD Genetic Variants Using Human iPSC-Derived Brain Cells," which investigates the genetic mechanisms underlying Alzheimer's disease (AD). Given that AD has an estimated...
The National Institute on Aging awarded Stony Brook University a Project Grant of $429,262 under the Aging Research program (CFDA 93.866) for research investigating ciliopathy features in mouse models of Down syndrome. The award period runs from February 1, 2026, through January 31, 2028. The research team will develop and apply novel techniques for live imaging and computational analysis of ciliated ependymal cells lining brain ventricles, including automated algorithms for quantifying ciliary beat frequency (CBF), analyzing ciliary motion, and characterizing cerebrospinal fluid (CSF) flow patterns. These advanced analytical methods are designed to characterize previously unrecognized features of ciliary function and arrangement in mutant mouse models, with the goal of understanding potential links between Down syndrome and impaired ciliary-mediated CSF circulation—a process critical for brain homeostasis, nutrient distribution, and adult neurogenesis. The research addresses a significant gap in understanding how trisomy 21 may disrupt ciliary function and CSF dynamics in the brain, potentially contributing to cognitive impairment associated with Down syndrome. By uncovering defects in ependymal cell architecture, ciliary motion, and fluid flow dynamics, this project advances fundamental knowledge relevant to aging-related neurological conditions and ciliopathies, aligning with the National Institute on Aging's emphasis on understanding age-related diseases and neurodegeneration through interdisciplinary biomedical research.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.3k | 1/20/26 |