Project Grant R21AG102510
- The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $518,555 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop spatially validated human lymphoid follicles-on-chip for modeling inflammaging and age-related immune dysfunction. The recipient will establish a lymphoid follicle organ-on-chip platform that recapitulates key hallmarks of human lymphoid function, including germinal center formation, AID expression, and antiviral antibody...
- The National Institute on Aging awarded $648,930 to the Regents of the University of California, doing business as University of California, Berkeley, on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop human stem cell-based microphysiological systems for aging research. The recipient will create a novel human aging-on-a-chip platform integrating fat and liver tissues derived from human induced pluripotent stem cells (hiPSCs) and microfluidics using serum from young...
- The National Institute on Aging awarded The Jackson Laboratory $506,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop an age-stratified human gut-on-chip model that integrates organoid-derived young and old colon epithelia with patient-derived microbiomes within a dynamically perfused, oxygen-controlled microphysiological environment. The recipient will establish the first such platform capable of sustaining obligate anaerobes and examining how aging-related...
- The National Institute on Aging awarded New York University $708,137 on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate technologies for probing the biophysical properties of aging cells. The funded work centers on developing genetically encoded multimeric particles (GEMs) as high-throughput microrheology probes to measure the physical properties of cell interiors—particularly within organelles including the nucleus, cytoplasm, endoplasmic reticulum,...
- The National Institute on Aging awarded Drexel University $420,554 under Aging Research (CFDA 93.866) on September 1, 2026, to establish an integrated system for studying senescence and aging in the central nervous system. The award funds two research aims: characterization of the molecular and functional consequences of senescence in astrocyte and neuronal cultures, and evaluation of senescence impact in a multicellular context using hiPSC-derived vascularized cortical organoids. Single-cell...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $298,419 to the Regents of the University of Michigan on February 1, 2026, under the Aging Research program (CFDA 93.866, Assistance Listing Project Grant R01AG097771). The recipient will develop advanced statistical and computational methods for analyzing immune cell data to enhance understanding of the immune system's role in aging and age-related diseases. The project addresses analytical...
- The National Institute on Aging awarded Emory University $643,613 on April 1, 2026, under the Aging Research program (CFDA 93.866) to discover glycosylation-based disease processes and identify glyco-biomarkers and targets for improving Alzheimer's disease diagnosis, prognosis, and intervention. The recipient will perform innovative research using an integrated platform of intact glycopeptide-based quantitative glycoproteomics and systems biology to elucidate brain glycoproteome alterations in...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $420,052 to Texas A&M Engineering Experiment Station on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop FlowGeroChips, a long-term microphysiological system for modeling age-related vascular dysfunction. FlowGeroChips replicates human aged arteriolar blood vessels using induced pluripotent stem cell-derived endothelial cells and vascular smooth muscle cells in a...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
The National Institute on Aging awarded Georgia TECH Research Corp $432,849 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a three-dimensional microphysiological organoid-on-chip platform that models aged human germinal center dynamics and evaluates sex-specific determinants of immune aging in human lymphoid tissues. The project combines high-dimensional cyclic immunofluorescence mapping of aged human lymph nodes with an organoid-on-chip system designed to recapitulate the biophysical, cellular, and molecular features of immune aging. The work addresses a critical gap in understanding human immune aging: while aging impairs antibody quality and germinal center function in humans, most research relies on murine models or static histological analyses that cannot capture live B-T cell interactions, germinal center polarization, or microenvironmental effects. The platform will model age-associated remodeling of the lymph node microenvironment and associated epigenetic dysregulation that disrupts germinal center polarization and antibody maturation in sex-dependent patterns. The research supports the National Institute on Aging's mission to understand aging and identify ways to prevent and treat age-related diseases. Performance occurs in Atlanta, Georgia. The award period runs from September 1, 2026, through August 31, 2028. Georgia TECH Research Corp, doing business as the Office of Sponsored Programs, is the research arm of the Georgia Institute of Technology and serves as the recipient institution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $432.8k | 8/21/26 |