Project Grant R21AG098547
- Federal Project Grant Award Summary The National Institute on Aging awarded The Washington University a $2.63 million Project Grant under the Aging Research program (CFDA 93.866) beginning September 1, 2025, with completion scheduled for August 31, 2029. This research initiative investigates age-related deficits in episodic memory for both content and structure of naturalistic events, with the objective of improving early detection of cognitive decline in at-risk older adults before...
- Federal Grant Award Summary The National Institute on Aging awarded The Washington University a $730,089 Project Grant effective June 1, 2025, through February 28, 2030, under the Aging Research program (CFDA 93.866). This award supports the Life-Space, Isolation, and Functional Exposome Study in Preclinical Alzheimer's Disease and Cognitive Environments (LIFESPACE), a longitudinal research investigation examining the relationship between social isolation, life-space constriction, and...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant totaling $1,851,569 under the Aging Research program (CFDA 93.866) for the period June 1, 2025, through March 31, 2030. This research initiative, titled "First In Last Out: How Development Informs Neurodegeneration," investigates the biological mechanisms linking early brain development to late-life Alzheimer's disease (AD) pathology. The project aims to empirically...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University a Project Grant of $593,146 under the Aging Research program (CFDA 93.866) effective January 1, 2026, through November 30, 2030. This award supports research investigating mechanisms of activity-dependent transcription and DNA repair in neuronal longevity. The research aims to define new mechanisms that promote neuronal DNA repair and transcriptional fidelity across the lifespan, with...
- Federal Grant Award Summary The National Institute on Aging awarded a $128,373 Project Grant to The Washington University (Office of Sponsored Research Services) on August 15, 2025, under the Aging Research program (CFDA 93.866) to support research comparing biological aging clocks across multiple physiological modalities. The primary deliverable is a rigorous comparative analysis of state-of-the-art epigenetic, proteomic, and neuroimaging-based biological age clock models using longitudinal...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Washington University a Project Grant totaling $556,121 (awarded January 15, 2026, with completion by December 31, 2030) under the Aging Research program (CFDA 93.866) to conduct scientific research on transgenerational adaptation of longevity changes in response to repeated environmental stresses. The research investigates how organisms—specifically Caenorhabditis elegans—adapt across successive generations when...
- Project Grant Award Summary The National Institute on Aging (NIA) awarded Washington University $771,627 through the Aging Research program (CFDA 93.866) beginning September 1, 2025, with completion targeted for August 31, 2030. This Project Grant supports the development and efficacy testing of a metacognitive strategy intervention designed to address Parkinson Disease (PD)-related cognitive decline. The research employs the Multicontext (MC) approach—a strategy training methodology that...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $1.37M Project Grant to Washington University (Office of Sponsored Research Services) under the Aging Research program (CFDA 93.866) effective January 1, 2026, through December 31, 2030. The award funds development of an innovative biocompatible fiber implant designed to enable long-term, deep-brain imaging and manipulation in mouse models of Alzheimer's disease. The implant integrates photoacoustic microscopy (PAM)...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Washington University a $3.19 million Project Grant effective September 1, 2025, through August 31, 2029, under the Aging Research program (CFDA 93.866). This project will develop and apply machine learning and artificial intelligence methods to systematically investigate multivariate relationships between amyloid-tau-neurodegeneration (ATN) biomarkers, neuropsychiatric symptoms, vascular risk factors, and...
- Federal Project Grant Award Summary The University of California, Santa Barbara received a $4.77 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) awarded August 5, 2025, with a completion date of July 31, 2029. This award supports a multi-principal investigator research initiative investigating the effects of endocrine aging on spatial navigation ability and associated neuronal systems. The research team, composed of experts in...
The National Institute on Aging awarded a $427,625 Project Grant to The Washington University (Office of Sponsored Research Services) on February 1, 2026, under the Aging Research program (CFDA 93.866) to support a two-year research initiative examining age-related differences in spatial navigation and cognitive mapping. The research will investigate how older adults acquire and retain flexible navigation behaviors—such as taking shortcuts through novel environments—over extended timeframes that more closely mirror real-world learning conditions. The study employs a longitudinal paradigm involving multi-day study-test trials across three days with a two-week retention interval, conducted in a real-world museum environment rather than a single-session virtual setting. This approach aims to address existing gaps in the literature by testing a theoretical model positing that age-related limitations in processing speed, attentional control, and associative processes contribute to slower acquisition of environmental knowledge and greater forgetting over time. The research products will advance understanding of the cognitive mechanisms underlying age-related navigation deficits and inform interventions to reduce anxiety and activity restrictions in older adults experiencing wayfinding difficulties. The project's real-world experimental design and extended retention intervals will yield empirical data on the evolution of environmental knowledge across longer timescales than typical laboratory studies, providing insights relevant to improving navigation capabilities and quality of life for aging populations. The award period extends through January 31, 2028.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $427.6k | 1/23/26 |