Project Grant R21AG098255
- The National Institute on Aging awarded the University of California, Berkeley $598,837 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate how hematopoietic stem cell aging affects distant tissues and organismal aging. The research will characterize a mouse model that reverses hematopoietic stem cell (HSC) aging by measuring changes in healthspan and lifespan and deciphering the molecular and cellular mechanisms underlying those alterations. The work tests the...
- The National Institute on Aging awarded Yale University $544,318 under the Aging Research program (CFDA 93.866) on June 1, 2026, to conduct research on immunometabolic regulation of inflammaging by nerve-associated macrophages (NAMs). The project investigates how nerve-associated macrophages—a subset of macrophages residing on sympathetic nerve fibers—regulate the sympathetic nervous system and innate immune response to control chronic inflammation associated with aging. The research addresses...
- The National Institute on Aging awarded New York University $705,405 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how changes in nuclear physical properties during cellular senescence drive transcriptional and splicing dysregulation characteristic of aging. The funded research measures nuclear biophysical properties across multiple length scales using a toolkit including genetically encoded multimeric nanoparticles (nucGEMS, 40–50 nanometers), newly...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $533,500 to the Buck Institute for Research on Aging on July 15, 2026, under the Aging Research program (CFDA 93.866). The award funds examination of the role of autonomic innervation in muscle stem cell aging. The research investigates the functional link between autonomic nervous system neurons and muscle stem cells using Drosophila melanogaster as a model organism. The project will refine...
- The National Institute on Aging awarded New York University $708,137 on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate technologies for probing the biophysical properties of aging cells. The funded work centers on developing genetically encoded multimeric particles (GEMs) as high-throughput microrheology probes to measure the physical properties of cell interiors—particularly within organelles including the nucleus, cytoplasm, endoplasmic reticulum,...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $298,419 to the Regents of the University of Michigan on February 1, 2026, under the Aging Research program (CFDA 93.866, Assistance Listing Project Grant R01AG097771). The recipient will develop advanced statistical and computational methods for analyzing immune cell data to enhance understanding of the immune system's role in aging and age-related diseases. The project addresses analytical...
- The National Institute on Aging awarded New York University $466,125 under the Aging Research program (CFDA 93.866) on January 15, 2026, to develop innovative magnetic resonance imaging analysis tools for identifying microstructural biomarkers of skeletal muscle health across the lifespan. The project, titled "(Micro)structural Biomarkers of Skeletal Muscle Health Across the Lifespan," addresses sarcopenia—a leading cause of disability and mortality in aging populations—by creating...
- The National Institute on Aging awarded the University of Rochester $656,829 under the Aging Research program (CFDA 93.866) on January 1, 2026, to investigate selective vulnerability of the fronto-insular network in aging and Alzheimer's disease through integrated structural, functional, and molecular analyses in mouse models. The research integrates in vivo two-photon imaging to track dendritic spine dynamics and dopaminergic terminal remodeling, fiber photometry to measure neural activity...
- The National Institute on Aging awarded the University of Rochester $599,180 on August 15, 2026, under the Aging Research program (CFDA 93.866) to establish and characterize an optical implant for intravital multiphoton microscopy of the murine intervertebral disc, enabling longitudinal visualization of cellular and matrix dynamics over time. The project will develop a right-angle prism-based imaging system placed adjacent to the spine that redirects laser light at 90 degrees to focus on the...
- The National Institute on Aging awarded Albany Medical College $246,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate inter-organelle dynamics during aging in eukaryotic cells. The work will characterize spatial contexts of inter-organelle communication using C. elegans as a model system to identify organellar signatures that develop during aging and proteostasis decline, establishing a platform to understand how aging impacts organelle interactions and...
The National Institute on Aging awarded the University of Rochester $227,250 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate macrophage spatial heterogeneity in regulating hematopoietic aging and inflammation-related stem cell dysfunction. The research examines how resident macrophages in different bone marrow microenvironments regulate hematopoietic stem cell (HSC) division symmetry and fitness during aging. Using intravital microscopy and HSC reporter mice, the project tests whether macrophages in resorptive bone cavities promote symmetric HSC division with compromised regenerative potential, while macrophages in non-resorptive cavities shelter HSCs from age-related inflammatory stress. Aim 1 tracks division symmetry features in vivo through subcellular allocation and daughter cell morphometry, comparing macrophage-HSC interactions across cavity types. The methodological innovation developed combines intravital microscopy with transcriptomic interrogation of cavity-resident cells to assess both stemness markers and differentiation patterns under inflammatory conditions associated with aging. Performance occurs at the University of Rochester in Rochester, New York, with a period of performance from September 1, 2026, through May 31, 2028. This project grant falls under the National Institute on Aging's mission to support biomedical and behavioral research directed toward understanding aging processes and diseases affecting older populations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $227.3k | 9/1/26 |