Project Grant R21AG095984
- Federal Project Grant Award Summary Brown University received a $438,625 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on August 15, 2025, with completion anticipated by July 31, 2027. The funded research project addresses the life cycle dynamics of senescent cells—cells that have permanently ceased dividing in response to molecular damage. The research will examine how the senescence phenotype evolves in both young and aged cells...
- Federal Grant Award Summary Brown University received a $770,702 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on September 20, 2025, with a completion date of May 31, 2030. The grant funds a research education program titled "Best Practices for the Measurement and Analysis of Cognitive Data in the International Health and Retirement Study (HRS) Family and Its Harmonized Cognitive Assessment Protocol (HCAP)." The program addresses...
- Federal Grant Award Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded the University of Virginia a Project Grant of $1,044,334 effective August 1, 2025, through May 31, 2030. This research award supports investigation into the mechanisms of ribosomal DNA (rDNA) instability during aging, with the goal of understanding how genomic instability—a hallmark of aging conserved across species—contributes to cellular aging processes. The project will...
- Federal Project Grant Award Summary Boston University Medical Campus received a $343,350 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded May 1, 2026, with a completion date of March 31, 2031. The grant funds biomedical research investigating the role of endogenous RNA interference (RNAi) mechanisms in aging control and lifespan extension. The research utilizes Caenorhabditis elegans as a model organism to examine how small RNAs (sRNAs) and...
- Federal Project Grant Award Summary Yale University received a $681,277 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded May 15, 2026, with a completion date of April 30, 2031. This grant funds research investigating cell size inheritance and innate immune memory, with particular focus on understanding how enlarged immune cells maintain proliferative capacity without transitioning into senescence. The research examines the role of...
- Federal Grant Award Summary The Buck Institute for Research on Aging received a $809,486 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion scheduled for January 31, 2031. This award supports biomedical research investigating the role of oxidation resistance 1 (OXR1) and retromer proteins in brain aging and Alzheimer's Disease and Related Dementias (ADRD). The research deliverables include...
- Federal Grant Award Summary Baylor College of Medicine received a $440,000 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded May 1, 2026, with completion scheduled for April 30, 2028. This exploratory research project delivers scientific research services focused on identifying epigenetic drivers of lifespan heterogeneity in budding yeast through advanced single-cell analysis technologies. The research employs single-cell transcriptomic and...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Massachusetts Medical School a Project Grant of $452,783 under the Aging Research program (CFDA 93.866) to conduct biomedical research on molecular mechanisms of neuronal cell death and neurodegeneration. The award, effective June 1, 2026 through May 31, 2028, supports investigation into context-specific molecular pathways that protect against age-related neurodegeneration and axon degeneration. The...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a Project Grant of $852,273 under the Aging Research program (CFDA 93.866), effective September 1, 2025, with completion targeted for May 31, 2030. This project delivers comprehensive research services focused on genetic mapping of N6-methyladenosine (M6A) and pseudouridine (Ps) RNA modifications in the aging human brain and their relationship to Alzheimer's disease...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $397,416 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 4, 2025, with completion targeted for May 31, 2027. Under this award, Principal Investigator Dr. Zintis Inde will conduct research to understand apoptotic dysregulation across neural cell types in normal aging and Alzheimer's disease (AD). The research...
Brown University received a $438,625 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) beginning June 1, 2026, with completion scheduled for May 31, 2028. The research project, titled "Dissecting Cell Cycle Arrest Phenotypes in Aging and Age-Associated Diseases," will investigate the quiescence-senescence continuum hypothesis—a theoretical framework proposing that cellular quiescence (reversible cell cycle arrest) and senescence (irreversible arrest) exist along a dynamic continuum rather than as distinct states. The research will examine which senescence hallmarks are shared with quiescent cells, characterize the quiescent cell secretome, and explore various quiescent states linked to stress-induced changes associated with aging and disease in tissue-resident quiescent cells. The deliverables under this award will advance fundamental understanding of cellular aging mechanisms through discovery research conducted at Brown University's Providence, Rhode Island facility. The project directly supports the NIA's mission to fund biomedical and behavioral research directed toward understanding the aging process and age-related diseases. Findings are expected to contribute to the broader knowledge base regarding reversibility of cellular fates and the molecular pathways determining transitions between cellular growth, quiescence, and senescence—insights with potential implications for therapeutic interventions in aging-related conditions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $438.6k | 5/25/26 |