Project Grant R21AG095699
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $1,459,072 on August 1, 2025, under the Aging Research program (CFDA 93.866) to conduct research on Alzheimer's Disease (AD)-related neurological dysfunction. The research will deliver scientific knowledge and methodological innovations focused on understanding how inhibitory interneurons—specifically parvalbumin (PVALB) and somatostatin (SST) cell types—contribute...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Boston University Medical Campus a $1.22 million Project Grant effective August 1, 2025, through April 30, 2030, under the Aging Research program (CFDA 93.866). This award supports multiscale modeling and empirical studies investigating the mechanisms underlying normal and pathological brain aging, with particular focus on myelin dystrophy, synaptic loss, and neuronal hyperexcitability in the neocortex. The...
- Federal Grant Award Summary The University of Pittsburgh received a $2,003,400 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 15, 2025, with completion targeted for August 31, 2029. This award supports research to characterize white matter injury in Alzheimer's disease (AD) and its relationship to AD pathology and cognitive outcomes. The project employs a novel neuroimaging methodology called Unhealthy White Matter...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $454,937 Project Grant to The Research Foundation for the State University of New York (Stony Brook University) under the Aging Research program (CFDA 93.866) to conduct research on "Regulatory Landscape of Neurodegeneration by Single-Cell Spatial Multiomics." The award, issued on February 15, 2026, with an ultimate completion date of January 31, 2028, supports investigation into the cellular and molecular...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of North Carolina at Chapel Hill $426,674 under the Aging Research program (CFDA 93.866) for a two-year project period from September 1, 2025, through August 31, 2027. This Project Grant funds research investigating the implications of long-range mossy cell signaling and connectivity in Alzheimer's disease (AD). The research focuses on understanding how glutamatergic mossy cells in the dentate...
- Federal Project Grant Award Summary Emory University received a $147,656 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with an award date of March 11, 2025 and project completion date of September 29, 2025. The grant supports the development of the first human locus coeruleus (LC) organoid model to advance understanding of Alzheimer's disease (AD) pathology. The research addresses a critical gap in AD knowledge by utilizing...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Jackson Laboratory a $486,750 Project Grant on June 15, 2026, under the Aging Research program (CFDA 93.866) to develop and validate an innovative tri-culture microphysiological system for studying Alzheimer's Disease (AD) pathology. The primary deliverable is a human glial-neuronal platform that integrates neurons, astrocytes, and oligodendrocytes on a microfluidic device to enable axonal maturation, myelination,...
- Federal Project Grant Award Summary The University of Rochester received a $656,829 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded January 1, 2026, through December 31, 2030, to conduct research investigating the selective vulnerability of the fronto-insular network in aging and Alzheimer's disease. The research integrates in vivo structural, functional, and molecular analyses with behavioral assessments in mouse models to understand how...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $458,622 to the Research Foundation For Mental Hygiene, Inc. (operating as the New York State Psychiatric Institute) under the Aging Research program (CFDA 93.866) effective March 1, 2026, with a completion date of February 29, 2028. The award funds research to elucidate the neuronal mechanisms of focused ultrasound-induced blood-brain barrier opening (FUS-BBBO) as a novel therapeutic intervention for...
- Federal Grant Award Summary The University of Pittsburgh received a $3.1 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2029. This award supports biomedical research investigating the mechanistic relationship between persistent DNA damage-induced immune responses and aging. Specifically, the research examines how the cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes)...
The National Institute on Aging (NIA) awarded the University of Pittsburgh a $424,913 exploratory Project Grant (R21 mechanism) under the Aging Research program (CFDA 93.866) for the period July 1, 2026 through June 30, 2028. This award funds research investigating LAMP5 (Lysosomal-Associated Membrane Protein 5) interneurons in the human entorhinal cortex—a brain region critical for memory function where Alzheimer's disease (AD) pathology appears earliest. The research addresses a significant gap in understanding, as prior investigations have linked declining cognitive function in preclinical AD patients to the loss of LAMP5-expressing interneurons, yet no studies to date have examined how these cells are affected by normative aging or AD within the human entorhinal cortex itself. Under this grant, the University of Pittsburgh will deliver research outputs characterizing the morphological, molecular, and anatomical profiles of LAMP5+ interneurons compared to other neurons in the entorhinal cortex layer 1, examining both normative aging and tau-related AD neuropathology. The research leverages postmortem brain tissue and human surgical brain resections to directly investigate these vulnerable neurons in the human brain. These exploratory studies represent a critical foundational step toward understanding the role of LAMP5+ interneurons in human entorhinal cortex function and their contribution to both normal aging and Alzheimer's disease pathogenesis.Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $424.9k | 6/18/26 |