Project Grant R21AG094596
- Federal Project Grant Award Summary The University of Texas at Austin received a $438,625 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2027. The award funds research investigating the heterogeneity of interneuron vulnerability in aging and Alzheimer's disease using advanced ultraplex correlative light and electron microscopy (CLEM) techniques. The research aims to decode why certain...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The University of Texas Health Science Center at San Antonio $150,104 on March 3, 2026, under the Aging Research program (CFDA 93.866) to support research on circadian reprogramming in cellular senescence through August 31, 2028. This Project Grant funds a fellowship training initiative designed to develop an independent investigator in the field of circadian aging. The research addresses the bidirectional...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $1.31M Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 1, 2026, with completion targeted for December 31, 2030. This research award supports an investigation into the role of Enhancer of Zeste Homolog 2 (EZH2), an epigenetic modifier, in cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD). The project will examine how EZH2-mediated...
- Federal Project Grant Award Summary The University of Texas Health Science Center at Houston received a $390,000 Project Grant award, effective March 1, 2026 through December 31, 2030, from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). This research initiative focuses on elucidating inter-organelle unfolded protein response (UPR) coordination and cellular proteostasis, specifically examining how cells...
- Federal Grant Award Summary The University of Texas Health Science Center at San Antonio received a $150,000 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) on September 18, 2025, with a completion date of May 31, 2030. This award supports the NeuroEpiomics Conferences, an international workshop series designed to cultivate and expand a global network of interdisciplinary researchers with expertise spanning neurology, brain imaging,...
- Federal Project Grant Award Summary The University of Texas Health Science Center at Houston received a $417,800 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 15, 2025, with a completion date of August 31, 2027. This research project investigates senescence induced by iron overload in the brain vasculature, with particular focus on sex-based differences in vulnerability to cognitive dysfunction. The research will...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Texas at Arlington $472,793 under the Aging Research program (CFDA 93.866) for a three-year project period running from September 1, 2025 through August 31, 2028. This Project Grant supports research to decouple reproductive aging from somatic aging by investigating the role of the mammalian target of rapamycin complex 2 (mTORC2) pathway, specifically the SGK-1 kinase component, in reproductive...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Texas Medical Branch at Galveston $1,112,821 under the Aging Research program (CFDA 93.866) for a five-year project period spanning January 1, 2026, through December 31, 2030. This Project Grant supports biomedical research investigating the interplay between microglia activation and tau oligomer polymorphs in cognitive resilience among Alzheimer's disease patients. The research focuses on...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $3.18 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 13, 2025, with completion targeted for July 31, 2029. This award supports research investigating the spatial organization and conformational ensembles of alpha-synuclein (α-syn) amyloids within cellular environments. The project delivers scientific research products...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $650,533 Project Grant from the National Institute on Aging (CFDA 93.866: Aging Research) effective February 1, 2026, through January 31, 2031. This research project investigates the contribution of intramural von Willebrand factor (VWF) to cerebrovascular dysfunction in amyloidosis, with particular focus on understanding how VWF accumulation within blood vessel walls promotes abnormal vascular...
The University of Texas Health Science Center at Houston received a $429,000 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded June 1, 2026, with completion targeted for May 31, 2028. The grant funds a two-year research initiative investigating the cellular and molecular mechanisms underlying lifespan extension in response to cold temperature exposure in Drosophila melanogaster. Specifically, the research examines how cold exposure activates coordinated intracellular programs involving mitochondrial remodeling, suppression of nutrient signaling pathways through O-glcNAcylation, and translational reprogramming to enhance protein quality control—mechanisms hypothesized to improve metabolic function, stress resistance, and longevity. The deliverables include scientific research outputs examining the role of the mitochondrial uncoupling protein UCP4B in mediating cold-induced metabolic shifts, investigation of cold-suppressed O-glcNAcylation as a regulator of mTOR and GSK3B signaling pathways, and characterization of translational remodeling mechanisms that promote proteostasis during aging. Research findings will advance understanding of aging mechanisms distinct from previously characterized cold-temperature aging pathways in other model organisms, potentially identifying therapeutic targets for age-related diseases. The NIA's Aging Research program supports biomedical and behavioral research directed toward understanding the aging process and diseases affecting older populations, with particular emphasis on neurodegenerative conditions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $429.0k | 5/19/26 |