This federal Project Grant award of $1,086,563 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to define the regulation of lysosome-mediated pathways (autophagy and endolysosomal) within and between astrocytes and neurons in response to proteotoxic stress elicited by fibrillar forms of α-synuclein. The research aims to elucidate cell-type-specific responses and vulnerabilities in neurodegenerative diseases such as Parkinson's, Alzheimer's, Huntington's,...
This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, provides $3,018,210 to Baylor College of Medicine under the Aging Research program (CFDA 93.866). The grant funds research to functionally dissect a promising transcriptional regulatory network linked to glutamate excitatory signaling that is downregulated in Alzheimer's disease and enriched for suppressors of neurodegeneration. Researchers will perform genetic manipulations in...
This $1,785,580 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop innovative spatial multi-omics technologies and apply them to comprehensively map cellular states and microenvironments in the human hippocampus under healthy and Alzheimer's disease conditions. The 5-year grant, awarded to the Trustees of the University of Pennsylvania, will: Create a novel technology for spatially co-profiling epigenome, transcriptome, and protein data in the...
This $246,248 federal Project Grant awarded on December 1, 2024 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research on the role of disrupted autophagy in the progression of Alzheimer's disease (AD) and related dementias. The principal investigator at The Trustees of the University of Pennsylvania will investigate how disturbances in the clearance of...
This federal Project Grant award, funded by the National Institute on Aging (part of the Department of Health and Human Services) under the Aging Research program (CFDA 93.866), is focused on evaluating a novel therapeutic approach to target neuroinflammation for protecting against brain aging and Alzheimer's disease-related pathology. The $281,962 award, with an end date of June 30, 2026, will support a series of preclinical studies in aging wild-type mice and transgenic mouse models of amyloid...
The National Institute on Aging (NIA) awarded a $498,748 Project Grant under the Aging Research program (CFDA 93.866) to the University of Massachusetts Medical School (UMass Medical) to elucidate the mechanisms by which MS4A genes regulate neurodegeneration in Alzheimer's disease and related disorders. The project aims to investigate the effects of deleting various MS4A gene family members, individually or in combination, on neurodegenerative phenotypes across mouse models of Alzheimer's,...
This Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to understand the mechanisms responsible for autophagy defects in neurons affected by Alzheimer's disease (AD). The project will evaluate the effects of clinically relevant inhibitors and modulators on rescuing neuronal autophagy defects and providing synaptoprotective and neuroprotective effects in a transgenic AD mouse model. The total award amount is $749,030.00, with a project period from...
This $125,896 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support the genetic and single-cell multi-omic characterization of Alzheimer's disease (AD) risk and resilience pathways. The Washington University in St. Louis will utilize state-of-the-art single-nuclei multi-omic functional genomic analyses of healthy and AD human brain tissue, as well as transgenic AD mouse models, to perform deep molecular profiling across genetic,...
This three-year Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund $2,136,033 in research under the Aging Research program (CFDA 93.866). The grant recipient, Case Western Reserve University in partnership with University Hospitals of Cleveland, will investigate the role of the CHCHD6 protein in Alzheimer's disease pathology and potential therapeutic interventions. Specifically, the researchers will study the causes and consequences...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $423,994 to Duke University to conduct research on characterizing spatial variations in RNA isoform expression associated with Alzheimer's disease (AD). The project will leverage single-nucleus cDNA, long-read RNA sequencing, and in situ sequencing to profile isoform expression at single-cell resolution in the inferior frontal gyrus, a brain region pertinent to AD. This multiomic approach aims...