This federal Project Grant award, with ID R01AG085398, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award totals $2,181,876 and will be performed between Sep 15, 2024 and May 31, 2029 by the University of Oklahoma Health Sciences Center. The key products and services to be delivered under this award aim to investigate the role of astrocyte mitochondrial function and proteostasis in driving cognitive impairment...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,027,220 to the Oklahoma Medical Research Foundation (OMRF) to investigate the role of the Major Histocompatibility Complex I (MHC-I) in regulating microglial function during aging and Alzheimer's disease. The research aims to determine if MHC-I expression modulates microglial reactivity and phagocytic phenotypes, impacts prodromal Alzheimer's disease symptoms and disease progression, and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,055,313 in funding to the University of Miami to conduct research on the role of glial cells in the aging process. Specifically, the researchers will leverage C. elegans genetics and advanced imaging and supplementation methods to investigate how the glial ion channel CLH-1 controls organismal aging. The key objectives are to establish the function of glial CLH-1 in influencing aging and to...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research Federal Grant Program (CFDA 93.866) provides $1,394,250 to the Icahn School of Medicine at Mount Sinai to study the molecular mechanisms underlying pathological aging of the human brain and adipose tissue, as well as their inter-organ communication. The project aims to investigate the heterogeneity of human aging and identify the common pathological aging mechanisms shared between the brain (e.g., hippocampus,...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $2,496,057.49 to the University of Arizona to investigate the role of hepatic glucagon receptor signaling in healthspan and aging. The research aims to study the impact of genetic and pharmacological manipulation of glucagon receptor signaling on normal aging, obesity-accelerated aging, and the effects of calorie restriction. This work seeks to identify glucagon receptor...
This $6,226,692 project grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support research to examine the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the development of Alzheimer's disease (AD). The primary focus is on investigating how modifications in brain activity, particularly in the locus coeruleus (LC) and hippocampus (HPC) regions, can lead to the key pathological hallmarks of AD....
The National Institute on Aging (NIA) awarded a $1,473,241 Project Grant under the Aging Research program (CFDA 93.866) to Mayo Clinic to investigate the role of adipose senescent cells in cognitive function and Alzheimer's disease progression. The 5-year award, effective August 15, 2024, will support research to determine if the aging- or obesity-driven accumulation of senescent cells in adipose tissue contributes to cognitive deficits and neurodegeneration, including Alzheimer's-related...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will provide $880,000 to Old Dominion University from September 2024 through August 2026. The project aims to investigate the therapeutic effects of microglia depletion and repopulation (MGDR) on mitigating hand and neuropsychiatric symptoms in the context of chronic HIV infection. Specifically, the research will explore the impact of MGDR on brain pathology in HIV-infected mouse models, examining its...
The National Institute on Aging (NIA) awarded a $442,357 Project Grant under the Aging Research program (CFDA 93.866) to the Research Foundation of the City University of New York (RFCUNY) on December 15, 2024. The grant aims to elucidate the molecular mechanisms that give rise to functionally neurodegenerative microglia, the brain's primary innate immune cells, which have been implicated as major determinants of Alzheimer's disease (AD) risk. The research will leverage novel mouse models and...