This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of O-GlcNAcylation in regulating astrocytic mitochondrial function and neuroinflammation in an Alzheimer's disease mouse model. The $406,817 award to the University of Alabama at Birmingham (UAB) will explore how changes in this post-translational protein modification impact mitochondrial dysfunction and neuroinflammation, which are key pathogenic...
This $705,775 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to map mitochondrial diversity in the aging brain and immune system. The goal is to establish cell type-specific mitochondrial recalibrations associated with age, cognition, and Alzheimer's disease (AD).
The research will leverage a novel computational "mitotyping" approach to profile mitochondrial biology at single-cell resolution in over 1.4 million brain...
This $2,027,220 federal Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) supports fundamental biomedical research conducted by the Oklahoma Medical Research Foundation (OMRF) to investigate the role of major histocompatibility complex I (MHC-I) in regulating microglial function during brain aging and the development of Alzheimer's disease. The 3-year project, running from September 2024 through August 2027, will utilize a novel, microglia-specific...
The University of Arizona received a $1,610,885 Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The research project aims to investigate how disruptions in astrocyte lipid metabolism contribute to the onset and progression of Alzheimer's disease (AD) pathologies. The key objectives are to: 1) determine how amyloid-beta triggers metabolic reprogramming and impairs fatty acid degradation in astrocytes, leading to lipid...
This Project Grant award, funded by the National Institute on Aging (CFDA 93.866 Aging Research), provides $1,542,972.00 to the University of Cincinnati to conduct research on the role of mitochondrial dysfunction and oxygen toxicity in driving tau hyperphosphorylation, a common feature of Alzheimer's disease and related dementias. The 5-year project, running from June 2024 to February 2029, will characterize tau pathology, examine the influence of the tau kinase GSK3B, and investigate...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $827,764 to the University of Southern California to investigate the potential neuroprotective effects of the mitochondrial-derived peptide MOTS-C in the context of Alzheimer's disease (AD) and its association with the APOE4 genotype. The research aims to determine if MOTS-C can protect against APOE4-related aging phenotypes and AD pathology, as well as explore the underlying mechanisms by...
This Project Grant award for $245,040 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research study at Yale University to investigate the relationship between neuronal and astrocytic dysfunction, cerebral metabolism, and vascular health in the context of Alzheimer's disease (AD) pathogenesis. The key objectives are to:
Behaviorally monitor the development of AD to determine disease onset.
Map deficits in neuronal/astrocytic function in relation to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $107,865 to Cedars-Sinai Medical Center to conduct research on the role of astrocyte reactivity and "reactive astrocyte memory" in aging-related neurodegenerative disease, with a focus on Alzheimer's disease. The key objectives are to: 1) define the molecular characteristics of reactive astrocyte memory using mouse models of acute neuroinflammation, 2) functionally test the...
The National Institute on Aging (NIA) awarded a $2,459,177 Project Grant (CFDA 93.866 - Aging Research) to Tufts University School of Medicine to study the role of "atypical astrocytes" (ATAs) in aging and Alzheimer's disease (AD). The research aims to determine the molecular and cellular properties of ATAs, their impact on astrocyte-mediated homeostasis, and their relationship with blood-brain barrier dysfunction. The project will utilize the APPNL-G-F mouse model of AD and involve...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) will provide $2,413,601.00 in funding from June 2024 to May 2027 to investigate the role of extracellular vesicles, particularly mitovesicles of mitochondrial origin, in Alzheimer's disease pathology.
The research aims to characterize the biology and function of mitovesicles in the brain, including their generation, secretion, transport, and uptake by different cell types. It...