Project Grant R21AG093405
- Federal Project Grant Award Summary The University of Pennsylvania received a $2.8 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective February 1, 2026 through January 31, 2031. This award supports a continuation of a prior Program Project Grant (PPG) focused on epigenetics of aging and age-associated diseases. The research investigates two primary areas: chromostasis (homeostatic mechanisms that maintain dynamic chromatin...
- Federal Grant Award Summary The University of Pennsylvania received a $109,076 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective November 27, 2025, with completion expected by May 31, 2030. This award funds research investigating the modulation of synovial mechanobiology to mitigate disease progression in osteoarthritis (OA), a condition affecting nearly 8% of the global population with particular burden among older adults. The...
- Federal Grant Award Summary The University of Pennsylvania received a $333,116 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), with performance period from September 1, 2025, through August 31, 2026. This award supports scientific research investigating the relationship between aging, telomere dysfunction, and intestinal stem cell (ISC) niche function. The research addresses how both natural aging and telomere failure suppress stromal support...
- Federal Project Grant Award Summary The University of Pennsylvania received a $6.72 million project grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded on September 15, 2025, with a completion date of August 31, 2029. This award funds research to develop short RNA therapeutics designed to combat TDP-43 proteinopathy, a pathological hallmark affecting approximately 50% of Alzheimer's disease cases, 45% of frontotemporal dementia cases, 97% of...
- Federal Grant Award Summary The University of Pennsylvania received a $487,500 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded August 15, 2025, with completion targeted for July 31, 2030. The grant supports research into the functional genomics of microglial phagocytosis to advance precision neuroimmune therapeutics for Alzheimer's Disease (AD). The research will develop the...
- Federal Grant Award Summary The University of Pennsylvania received a $243,000 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective September 5, 2025, with completion targeted for May 31, 2030. This research project investigates the impact of frailty on disease relapse and therapy intensity in older adults with acute myeloid leukemia (AML), with emphasis on identifying biomarkers and optimizing treatment selection strategies. The...
- The University of Pennsylvania received a $446,875 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective September 1, 2025 through August 31, 2027. This research project will deliver scientific investigation into the genetic and molecular mechanisms of cellular senescence using Drosophila (fruit fly) models, with particular focus on understanding how senescent cells in the brain contribute to age-related decline. The research will...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Tufts University School of Medicine a $470,000 Project Grant under the Aging Research program (CFDA 93.866) on February 1, 2026, with a completion date of January 31, 2028. This grant funds research titled "Elucidating the Interplay Between AD Genetic Variants Using Human iPSC-Derived Brain Cells," which investigates the genetic mechanisms underlying Alzheimer's disease (AD). Given that AD has an estimated...
- Federal Project Grant Award Summary Pennsylvania State University, operating as Penn State Milton S. Hershey Medical Center, received a $777,296 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2027. The award supports fundamental biomedical research investigating the role of Polycomb Repressive Complex 1 (PRC1) in cellular aging of the brain. The research will elucidate how PRC1 regulates...
- Federal Project Grant Summary The University of Pennsylvania received a $427,919 project grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with a completion date of July 31, 2027. The grant supports the development of integrated micro-to-macro network models to advance understanding of disease progression in frontotemporal dementia (FTD). The research deliverables include the creation of a multi-scale network framework that...
The University of Pennsylvania received a $446,875 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded January 15, 2026, with a completion date of December 31, 2028. This research project investigates how specific genetic variants and aging jointly influence polyunsaturated fatty acid (PUFA) metabolism in white adipose tissue (WAT) using human-derived induced pluripotent stem cells (iPSCs) differentiated into white adipocyte-like cells. The research addresses mechanisms by which the PNPLA3-I148M genetic variant and aging synergistically affect eicosanoid production and metabolic dysfunction, with implications for understanding metabolic disorders and neurodegenerative diseases associated with disrupted WAT function. The project delivers scientific research outputs examining the gene-by-age interaction effects on PUFA accumulation and eicosanoid metabolism in adipocytes. Through this three-year funding period, the research team will generate experimental data characterizing how genetic variants influence arachidonic acid release from adipocyte membranes and subsequent eicosanoid production, contributing to the NIA's mission to support biomedical research directed toward greater understanding of the aging process and age-related diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $446.9k | 1/14/26 |