Project Grant R01AG097715
- Federal Project Grant Award Summary Duke University's Office of Research Administration is executing a scientific research project funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The $715,801 project grant, awarded June 1, 2025, with completion scheduled for March 31, 2030, supports biomedical research investigating the mechanisms linking hypertension and aging to postoperative delirium and subsequent Alzheimer's disease and related dementias...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $242,250 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025 through August 31, 2027. This R03 feasibility study, led by Dr. Selvaraj, delivers research services investigating regional metabolic changes during exercise in patients with heart failure with reduced ejection fraction...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $242,250 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 1, 2025, through June 30, 2027. The award funds a research study examining the interplay between atrial fibrillation (AF), anticoagulation therapy, and retinal stroke using instrumental variable analytical methods. The research addresses a...
- Grant Award Summary Duke University's Office of Research Administration received a $243,000 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through June 30, 2030. The INSPIRE-COPD-E (Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations) project will conduct scientific research to identify biological mechanisms underlying chronic obstructive pulmonary disease...
- Federal Grant Award Summary Duke University received a $1.48 million Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 15, 2025, through June 30, 2029. The project delivers research and development services focused on improving intensive care unit (ICU) mortality risk prediction accuracy. The award supports the creation of a novel ICU mortality risk prediction model designed to...
- Federal Grant Award Summary Duke University received a $165,456 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 15, 2025, with completion targeted for June 30, 2030. This award funds research investigating the role of protein S-palmitoylation in transforming growth factor beta (TGF-β) signaling and its contribution to idiopathic pulmonary fibrosis (IPF). The research deliverables include...
- Federal Grant Award Summary The University of Virginia received a $689,148 Project Grant award from the National Institute on Aging (CFDA 93.866, Aging Research) with an award date of February 1, 2026, and completion date of January 31, 2031. This research project investigates the profibrotic effects of hematopoietic Y chromosome loss (mLOY) in heart failure with preserved ejection fraction (HFpEF). The research will explore the clinical, causal, and mechanistic relationships between mLOY—the...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $158,652 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through August 31, 2030. This award funds a five-year research initiative titled "The Post-Lung Transplant Impact of Alveolar Macrophage Senescence in Aged Donor Lungs," which investigates the underlying...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute awarded The Johns Hopkins University a Project Grant totaling $126,387.00 on June 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on heart failure with preserved ejection fraction (HFpEF). The research will be performed in Baltimore, Maryland, with an ultimate completion date of April 30, 2027. The project investigates the mechanistic relationship between reduced...
- Federal Project Grant Award Summary The University of Missouri System received a $429,394 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded December 15, 2025, with completion targeted for November 30, 2027. This research initiative addresses heart failure with preserved ejection fraction (HFpEF) in aging populations with comorbid conditions such as obesity and hypertension. The project focuses on investigating LARP6 (LA...
The National Institute on Aging awarded Duke University a $680,818 Project Grant effective February 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866) to conduct the INFUSE HFPEF (Iron Needed for Function and Undesirable Symptoms in Elderly with Heart Failure with Preserved Ejection Fraction) study. This double-blind, placebo-controlled randomized clinical trial will evaluate the efficacy of intravenous iron supplementation in 300 ambulatory older adult patients with heart failure with preserved ejection fraction (HFPEF) and iron deficiency. The study will assess net clinical benefit through patient-centered outcomes including a composite endpoint of mortality, all-cause hospitalization, and health-related quality of life, alongside measurements of physical function. Duke University will execute this research in collaboration with Kaiser Permanente Northern California, Mount Sinai Health System, and St. Luke's Mid America Heart Institute. The project addresses a critical knowledge gap in treating iron deficiency in HFPEF, the fastest-growing heart failure phenotype affecting over 3 million older adults in the United States. By prioritizing patient-reported outcomes alongside traditional clinical endpoints, the study incorporates innovative patient-centered methodology aligned with contemporary FDA guidance on heart failure trials and reflects the growing importance of quality-of-life measures in geriatric cardiovascular research.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $680.8k | 1/30/26 |