Project Grant R01HL178999
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $197,640 to Dr. Lee Goeddel at Johns Hopkins University to conduct research on the relationship between cardiac output, renal perfusion, and the development of acute kidney injury in cardiac surgery patients. The project aims to leverage Dr. Goeddel's expertise in data science, biomarkers, and ultrasound imaging to better understand the mechanisms behind this...
- This federal Project Grant award of $193,984 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the interplay between inflammation, angiogenesis, myocardial perfusion, and myocardial function in patients with advanced chronic kidney disease (CKD). The project, conducted by Brigham & Women's Hospital Inc., aims to mechanistically explore cardiovascular health before and after kidney transplantation. Key objectives...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $189,000.00 to the University of Utah to support a 5-year mentored research program and plan. The goal is to develop the principal investigator into an independent, patient-oriented clinical researcher focused on the pathophysiology of cardiogenic shock and its overlap with cardiorenal syndrome. The central hypothesis is that angiotensin II deficiency in a...
- This Project Grant award of $1,631,690.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) supports a research project titled "Proteomic Signatures of Delirium and Long-Term Cognitive Decline in Older Cardiac Surgical Patients." The project aims to use state-of-the-art proteomics analysis to derive and validate a delirium protein signature for cardiac surgery patients, leveraging plasma samples from an ongoing...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Baylor College of Medicine aims to leverage machine learning analysis of electronic medical record data to develop new clinical decision support tools for early prediction and mitigation of acute kidney injury (AKI) after cardiac surgery. The $613,399 award, made on September 16, 2025, will support the development of personalized machine learning algorithms and...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) is for the research project "Impact of Hypertension and Aging on Postoperative Delirium". The $715,801 grant, awarded on June 1, 2025, supports Duke University's research to elucidate the contributions of endothelial cells and perivascular macrophages to surgery-induced neuroinflammation, blood-brain barrier disruption, and delirium-like behavior in aging and hypertension. The overarching...
- This federal Project Grant award of $169,344 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to advance the management of critically ill adults with non-ARDS acute hypoxemic respiratory failure (NAHRF). The key objectives are to: 1) Develop clinical prediction models for mortality in NAHRF patients; 2) Apply machine learning to detect NAHRF subphenotypes associated with differential clinical outcomes; and 3) Use sequencing-based whole...
- This federal Project Grant award, valued at $209,832.00 and provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, will support research at New York University (NYU) to improve the understanding of the role of the autonomic nervous system (ANS) in the cardiovascular complications of chronic kidney disease (CKD). The 5-year project aims to develop the candidate's skills in ANS...
- This federal Project Grant award of $3,010,432 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding research to develop mitoprotective therapies for the treatment of acute kidney injury (AKI). The key objectives of this research are to characterize a novel mitochondrial protein target, phospholipid scramblase 3 (PLSCR3), and evaluate pharmacological activators...
- This $268,500 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) will support the "Incident Hemodialysis Electrolyte Analysis and Rhythm Trends (IHEART)" study conducted by Dr. Katherine Ravi at Brigham & Women's Hospital. The study aims to investigate how cardiac rhythm morphology associated with sudden cardiac death evolves during the early stages of...
This federal Project Grant award, totaling $813,284.00 and provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports a research study on the relationship between acute kidney injury (AKI) and delirium in patients who have undergone cardiac surgery. The key objectives of this 5-year study are to: 1) determine the incidence and clinical characteristics of AKI-associated delirium in cardiac surgery patients, 2) delineate the signaling pathways involving inflammation and endothelial activation that are associated with AKI-related delirium, and 3) test whether higher levels of endogenous high-density lipoprotein are associated with less AKI and AKI-related delirium. The project aims to advance the mechanistic understanding of delirium after cardiac surgery and identify potential therapeutic targets by exploring the links between AKI and delirium in this patient population.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $813.3k | 9/17/25 |