Project Grant R21AG087016
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,041,438 to develop new computational tools and biomarkers for Alzheimer's disease. The University of Miami will aggregate and analyze DNA methylation datasets to identify age-associated epigenetic changes related to aging and Alzheimer's progression. Researchers will create a searchable web interface to disseminate findings on the role of DNA...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $320,511 project grant to TRU Diagnostics Inc. to develop a novel diagnostic tool for chronic diseases. The project aims to create a "non-stochastic W function epigenomic roadmap" using systems-based dynamic modeling to capture the shifting homeostatic set points of epigenetic markers over time. This transformative approach aims to enable personalized, dynamic health forecasts...
- This federal Project Grant award of $291,913 was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to Virscio, Inc., a for-profit research company located in Connecticut. The award is focused on developing epigenetic and senescent biomarkers using non-human primate tissues to advance the understanding of biological aging processes and potential anti-aging strategies. The project aims to create minimally invasive biomarker tools, such as blood and skin-based assays,...
- This federal Project Grant award for $1,249,147.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant is a collaborative effort between Epicypher, Inc., a biotechnology company in Durham, North Carolina, and Dr. Nicolas Young of Baylor College of Medicine to develop a novel platform called AgingPTM for studying aging-associated combinatorial histone post-translational modifications (ACPTMs) in tissue. This platform is intended to...
- This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
- This Project Grant award of $506,404.00 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate mechanisms of local and global epigenetic changes that drive senescence and aging-associated phenotypes. Key research objectives include: Examining how enhancers are rewired during senescence and aging, focusing on large enhancer communities or "cliques" and identifying transcription factors that drive their formation....
- This federal Project Grant award of $498,366.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop a platform for high-resolution imaging of peripheral blood mononuclear cells (PBMCs) in arrays of microscopic conical wells to assess biological age. The project, led by the University of California, San Diego, seeks to effectively implement an imaging-based chromatin and epigenetic age (IMAGE) analysis approach that captures changes in chromatin organization and...
- The National Institute on Aging (NIA) awarded a $205,000 project grant to The University of Texas Southwestern Medical Center (UT Southwestern) under the Aging Research federal grant program (CFDA 93.866) to implement an innovative optical MRI (OMRI) technique for time-resolved visualization of clock gene expression patterns in living mouse brains. The project aims to leverage the strengths of bioluminescent imaging and MRI to precisely track rhythmic gene expression, with a focus on the PER2...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $793,777 to the J. David Gladstone Institutes to conduct research on the impact of mitochondrial genome architecture on the accumulation of somatic mitochondrial DNA (mtDNA) mutations over an individual's lifetime. The primary goal is to understand how mtDNA compaction influences mutation rates and mitochondrial health, with potential implications for the prevention and treatment of...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $306,871 Project Grant to Fluid Discovery, Inc. under the Aging Research Federal Grant Program (CFDA 93.866). The grant supports the translation and commercial development of FIND-SEQ, a novel cell sorting technology that enables the isolation and profiling of rare cells in primary human tissues, even without known surface markers. This fast-track Small Business Innovation Research (SBIR)...
This $528,000 federal project grant, awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports the development of advanced single-cell whole-genome bisulfite sequencing technology to enable application of epigenetic clocks and in-depth characterization of DNA methylation biology. The grantee, Van Andel Research Institute (VAI) in Michigan, will leverage newly developed lineage tracing technology to conduct single-cell analysis and gain insights into the mechanisms underlying age-associated changes in cell populations versus progressive DNA methylation within individual cells. This research aims to resolve key questions in epigenetic clock research and advance the understanding of biological aging processes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $528.0k | 9/3/25 |