Project Grant R21AG079196
Award Date
9/1/23
Completion Date
8/31/25
Dollars Obligated
$422K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Florida, USA
Similar Awards
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $431,132 to Albert Einstein College of Medicine to explore the link between loss of the Y chromosome (LOY) and the aging process. The research aims to: Ascertain the extent of LOY mosaicism using sequencing data Identify genes that heighten LOY risk Decode the relationship between LOY and aging The award includes a $312,609 sub-grant to Rutgers, The State University of New Jersey to...
The National Institute on Aging awarded a $851,002 Project Grant (CFDA 93.866 - Aging Research) to Arizona State University (ASU) to systematically investigate the genetic contributions of sex chromosomes to Alzheimer's disease (AD). The project aims to re-align and re-analyze large amounts of next-generation sequencing data from clinical AD cohorts, with a focus on identifying variants and gene expression patterns on the X and Y chromosomes that may contribute to sex differences in AD. The...
The National Institute on Aging (NIA) awarded a $125,896 Project Grant under the Aging Research program (CFDA 93.866) to The Washington University in St. Louis to conduct research on Alzheimer's disease (AD) risk and resilience pathways. The project aims to perform deep molecular characterization of AD genetic risk factors and protective mechanisms using state-of-the-art single-cell multi-omic analyses of healthy and AD human brain tissue, as well as transgenic AD mouse models. Key objectives...
The National Institute on Aging (NIA) awarded a $350,001 Project Grant (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) to unravel the role of clonal hematopoiesis (CH) in neurodegenerative diseases. The project will leverage genomic and functional data to investigate the associations between different CH types, including clonal hematopoiesis of indeterminate potential (CHIP), autosomal mosaic chromosomal alteration (MCA), and loss of the Y chromosome...
The National Institute on Aging (NIA) awarded a $828,534 Cooperative Agreement under the Aging Research federal grant program (CFDA 93.866) to the University of Massachusetts Medical School (UMass Medical) to conduct a molecular dissection of the neuronal-adaptive immune-genomic axis. The goal is to identify novel integrative factors contributing to Alzheimer's disease (AD) pathogenesis or to the protection of brain neurons in the aging process. The project will apply large-scale, innovative,...
This $3,845,311 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research at the University of California, San Diego (UCSD) to investigate early determinants of Alzheimer's disease (AD) using patient-derived induced neurons (iNs). The project aims to better understand the mechanisms that cause mild cognitive impairment (MCI) and the progression to AD, integrating multi-omic analysis of MCI patient-specific iNs with polygenic risk scores....
This Project Grant award of $431,750 from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research to investigate the interaction between biological sex and APOE genotype in modulating Alzheimer's disease (AD) risk. The research will leverage human induced pluripotent stem cell lines with various APOE genotypes and sex chromosome complements to examine how APOE and sex influence amyloid-beta processing, tau hyperphosphorylation, and transcriptional changes...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) provides $835,825 to the University of Massachusetts Medical School to conduct research on somatic mutations in Alzheimer's disease. The project aims to analyze patterns of somatic single nucleotide variants, short insertions/deletions, and structural variants in neurons from Alzheimer's disease brains across disease progression. It will also examine how these...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Emory University will develop the first human locus coeruleus (LC) organoid model to study the role of the LC in the earliest stages of Alzheimer's disease (AD). The $147,656 award, which runs from March 2025 to September 2025, will validate the structure and function of the LC organoids, combine them with cortical organoids to define LC-cortex connectivity, and compare the pathology of LC organoids...