Project Grant RF1AG098887
- Federal Project Grant Award Summary The National Institute on Aging awarded Massachusetts General Hospital a $487,574 Project Grant on May 15, 2025, under the Aging Research program (CFDA 93.866) to conduct biomedical research investigating the role of reactive astrocytes in the propagation and clearance of tau pathology in Alzheimer's disease. The project, with a completion date of February 28, 2030, will deliver scientific research outputs aimed at understanding whether glial fibrillary acidic...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital a $1.58 million Project Grant on March 15, 2025, under the Aging Research program (CFDA 93.866) to conduct research characterizing microvascular impairment in adults with elevated genetic risk for Alzheimer's disease. The research initiative, which extends through January 31, 2030, investigates the physiological mechanisms through which the apolipoprotein E-epsilon 4 (APOE-E4) allele—the...
- This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,173,794 to The General Hospital Corporation (Massachusetts General Hospital) to conduct research on enhancing brain resilience to Alzheimer's disease by targeting adult hippocampal neurogenesis. The project aims to explore the mechanisms by which adult hippocampal neurogenesis cooperates with brain-derived neurotrophic factor (BDNF) to potentially slow cognitive decline in...
- Federal Grant Award Summary The National Institute on Aging awarded a $684,567 Project Grant to Massachusetts General Hospital (The General Hospital Corporation) for a four-year research initiative beginning March 1, 2026 and concluding December 31, 2029, under the Aging Research program (CFDA 93.866). The grant supports a resubmission methodology study designed to assess the utility of 64Copper-Fibrin-Binding-Probe-8 Positron Emission Tomography (64Cu-FBP8 PET) for in vivo detection and...
- Summary of Federal Project Grant Award The National Institute on Aging awarded $129,330 in Project Grant funding to Massachusetts General Hospital (The General Hospital Corporation) under the Aging Research program (CFDA 93.866) for the period June 15, 2025 through March 31, 2030. This award supports research addressing the critical challenge of early detection and accurate diagnosis of Alzheimer's Disease and Related Dementias (ADRD) through development of a machine learning-based prediction...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $459,250 under the Aging Research program (CFDA 93.866) on June 1, 2025, for a two-year project extending through May 31, 2027. This project grant supports longitudinal research investigating the mechanisms by which stress and resilience influence cognitive aging and Alzheimer's disease (AD) progression. The research will analyze existing data from two natural history,...
- Federal Project Grant Award Summary Brigham & Women's Hospital Inc. received a $492,250 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) to investigate the functionality of regulatory T cells (Tregs) in Alzheimer's disease. The award, obligated on September 15, 2025, with an ultimate completion date of August 31, 2027, supports research examining whether Tregs become dysfunctional in Alzheimer's disease patients. The research seeks to...
- Federal Project Grant Award Summary Brigham & Women's Hospital Inc. received a $3.69 million Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective September 15, 2025, through September 14, 2029. The award supports the development of specialized large language models (LLMs) designed to optimize comparative effectiveness research (CER) in Alzheimer's disease and related dementias (ADRD). The project addresses a critical gap in...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a $1,459,072 Project Grant on August 1, 2025, under the Aging Research program (CFDA 93.866) to investigate inhibitory neuron dysfunction in Alzheimer's disease (AD). The research will develop and implement innovative methodologies to monitor and manipulate two distinct inhibitory interneuron cell populations—parvalbumin (PVALB) and somatostatin (SST) cells—in both wildtype and AD-knock-in...
- Federal Grant Award Summary Brigham & Women's Hospital Inc. received a $6.47 million R01 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 1, 2025, with completion scheduled for August 31, 2030. The grant funds the Ante-Amyloid Treatment of Alzheimer's Disease (A3) Trial and the Alzheimer Plasma Extension (APEX) Study, which are components of the AHEAD 3-45 clinical trial initiative. The A3 Trial is a Phase IIB prevention...
Massachusetts General Hospital (The General Hospital Corporation) received a $3.17 million Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective February 15, 2026 through February 14, 2030. The award funds development and evaluation of cell therapy approaches to treat Alzheimer's disease by restoring inhibitory neural circuit function. The research focuses on transplanting embryonic mouse medial ganglionic eminence (MGE)-derived interneuron progenitors into animal models of amyloidosis to restore slow wave brain activity disrupted in Alzheimer's patients, with the goal of rescuing sleep-dependent memory consolidation and slowing disease progression. To increase translational applicability, the project will also test human induced pluripotent stem cell (iPSC)-derived interneuron progenitors in animal models. The National Institute on Aging supports this work under the Aging Research program's mandate to fund comprehensive scientific investigations directed toward greater understanding of the aging process and age-related diseases, with particular emphasis on Alzheimer's disease and related dementias. The research represents a stem cell-based therapeutic approach to address circuit hyperexcitation and aberrant neural oscillations characteristic of early Alzheimer's pathology, bridging laboratory discoveries with potential clinical applications through translational research methodology.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 2/6/26 |