Project Grant R01NS136684

This National Institute on Aging (NIA) federal Project Grant award (CFDA 93.866 - Aging Research) provides $757,027 to the University of Washington to study the synergistic relationship between the tau and TDP-43 proteins in Alzheimer's disease (AD). The 5-year project, starting January 1, 2025 and ending December 31, 2029, aims to investigate the mechanisms underlying how tau and TDP-43 pathologies interact to drive more rapid cognitive decline and hippocampal atrophy in AD. The research will...

This Project Grant award from the National Institute on Aging's Aging Research Program (CFDA 93.866) provides $717,709 to Weill Medical College of Cornell University to conduct research on the cellular mechanisms underlying the propagation of misfolded tau protein aggregates in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The key objectives are to: 1) Determine how amyloid-beta and tau seeding influence tau protein interactomes in human neurons expressing different tau isoforms;...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $460,625.00 to the University of Massachusetts Medical School (UMass Medical) to investigate the roles of the deubiquitylation pathway in regulating the subcellular localization and aggregation of TDP-43 protein, which is implicated in amyotrophic lateral sclerosis (ALS) and...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $251,250 to the University of Massachusetts Medical School (UMass Medical) to investigate the role of TDP-43 dysfunction in altering innate immune pathways and microglial function in models of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research...

This Project Grant award of $320,000 from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) is supporting research at the University of Texas Medical Branch at Galveston (UTMB) to investigate the impact of pathological tau protein on alternative polyadenylation (APA) regulation in Alzheimer's disease. The study aims to comprehensively profile APA transcripts and gene expression in mouse primary hippocampal neurons expressing wild-type and mutant tau proteins....

This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $3,727,176 to the University of North Carolina at Chapel Hill to conduct research on environmental risk factors linked to TDP-43 proteinopathies, which are associated with neurodegenerative diseases like frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and Alzheimer's disease. The project aims to identify environmental toxicants that mediate TDP-43...

This $603,031 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Northwestern University supports a 1-year research study on the clinical, cellular, and pathological features of comorbid Alzheimer's disease and TDP-43 proteinopathies in elderly patients with amnestic dementia. The key objectives are to: 1) identify the shared versus distinct clinical, neuropsychological, and psychiatric characteristics of this condition; 2) determine the cellular...

This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) in the amount of $442,750 aims to develop synthetic replicas of TDP-43 protein filaments associated with frontotemporal dementia and other neurodegenerative diseases. The research, conducted by Case Western Reserve University, seeks to establish conditions for generating in vitro amyloid fibrils with structures identical to brain-derived TDP-43 filaments. Generating these...

The National Institute on Aging (NIA), under the Federal Grant Program for Aging Research (CFDA 93.866), awarded a $404,058 Project Grant to the Regents of the University of Minnesota to develop a novel approach to restore functional TDP43 for the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The grant aims to identify small molecule compounds that can stabilize functional, multimerized TDP43 in order to rescue TDP43-associated pathologies. This will be...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will be used to develop a human-mouse chimeric brain model for studying tau pathology in human neurons in vivo. The $274,750 award will enable the researchers at Purdue University to characterize the spatiotemporal patterns of tau pathology and associated cognitive dysfunction...