Project Grant R21AG092912
- The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $475,475 on July 15, 2026, under the Aging Research program (CFDA 93.866) to investigate suburothelial myofibroblast function in young and aging bladder tissue. The research addresses lower urinary tract symptoms affecting the aging population by examining how suburothelial myofibroblasts (SUMFs)—interstitial cells beneath the bladder's urothelial lining—contribute to normal bladder function and dysfunction during...
- The National Institute on Aging awarded the University of Pittsburgh $437,250 on July 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a randomized controlled trial examining behavioral sleep intervention and brief mindfulness as treatments for nocturia in older women. The study, titled "Addressing Nocturia in Older Women Utilizing Behavioral Sleep Intervention and Brief Mindfulness" (ANOWSM), will enroll 60 women aged 65 and older with nocturia and poor sleep and...
- The National Institute on Aging awarded The Methodist Hospital Research Institute $665,617 on September 15, 2026, under the Aging Research program (CFDA 93.866) to identify age and sex-dependent contributions to supraspinal mechanisms involved in underactive bladder dysfunction. The research addresses the poorly understood neurological underpinnings of underactive bladder (UAB), which presents with symptoms including slow urinary stream, hesitancy, and incomplete emptying. UAB predominantly...
- The National Institute on Aging awarded the University of California, San Diego $182,173 on March 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how noradrenergic modulation during non-rapid eye movement sleep relates to memory consolidation and to test whether precise timing of cortical slow oscillations, thalamic spindles, and hippocampal sharp wave-ripples orchestrates memory transfer from hippocampus to cortical long-term memory. The research aims to understand how...
- The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $3,481,644 on August 1, 2026, under the Aging Research program (CFDA 93.866) to investigate mechanisms by which excessive amyloid-beta peptides impair brain lymphatic function and contribute to Alzheimer's disease and Down syndrome. The research program comprises three strategic aims. The first involves extensive molecular, cellular, structural, and functional analyses of brain lymphatics in mouse models of...
- The National Institute on Aging awarded Tufts Medical Center Parent, Inc. (doing business as Tufts Medical Center) $357,000 under the Aging Research program (CFDA 93.866) on September 1, 2026, to investigate endothelial pannexin1-induced inflammation in Alzheimer's disease. The research tests the hypothesis that amyloid-beta upregulates cerebral endothelial pannexin1 expression, which promotes vascular dysfunction and Alzheimer's disease progression through increased neuroinflammation and...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $249,000 to The Regents of The University of Colorado on July 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research investigating how beta-amyloid accumulation impacts hypocretin neuron activity and subsequently disrupts sleep architecture in Alzheimer's disease. The research examines whether beta-amyloid accelerates death of hypocretin neurons...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $450,200 on May 15, 2026, under the Aging Research program (CFDA 93.866) to map age-dependent changes in primary sensory neurons and nociceptors. The recipient will deliver a systematic, cell-type-resolved map of how normal aging remodels peripheral sensory neurons housed in the dorsal-root ganglion (DRG). The project employs subtype-specific labeling via a recently published molecular-genetic...
- The National Institute on Aging awarded the University of Southern California $149,190 on August 6, 2026, under the Aging Research program (CFDA 93.866) to investigate how early-stage Alzheimer's disease disrupts coordinated release dynamics between acetylcholine and norepinephrine in the cortex and how this discoordination impairs cognitive performance. The research characterizes the evolution of coordinated cortical acetylcholine and norepinephrine release activity in vivo in wildtype mice,...
- Federal Grant Award Summary The National Institute on Aging awarded a $162,200 Project Grant to The Research Foundation for the State University of New York (doing business as SUNY Downstate Health Sciences University) under the Aging Research program (CFDA 93.866). The award, issued August 15, 2025, with a completion date of July 31, 2027, supports a pilot research study investigating vasopressin 2 receptor (V2R) expression and function in the bladder across different age groups and...
The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $475,475 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate neural mechanisms underlying nocturia-related arousals in aging. The recipient will conduct research examining why 60–70 percent of individuals aged 60 and older experience frequent nighttime bladder emptying trips despite absence of urodynamic dysfunction. The study hypothesizes that decreased arousal threshold resulting from a hyperexcitable wake-promoting system drives nocturia, with particular focus on noradrenergic neurons in the locus coeruleus (LC). In Aim 1, researchers will image LC neuronal population activity dynamics during spontaneous bladder fill-void cycles across sleep-wake states in young and aged mice, then modulate bladder volume via implanted saline catheter during sleep to determine the precise association between LC activity and bladder-evoked arousals. In Aim 2, the team will inhibit LC neurons using chemogenetic methods or increase their excitability using optogenetic methods to study resulting changes in bladder-evoked arousals across age groups. Based on pilot data, the investigators predict LC neurons will be overactive in aged mice, driving increased arousals. Work is performed at Boston, Massachusetts with a period of performance from September 1, 2026 through August 31, 2028. The award is classified as a Project Grant, an assistance type used for biomedical research and research training directed toward understanding aging and age-related diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $475.5k | 8/28/26 |