Project Grant R21AG091377
- Federal Project Grant Award Summary Case Western Reserve University's Office of Research Administration received a $431,750 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective January 1, 2026, through December 31, 2027, to conduct biomedical research on the role of CHCHD10 protein in tauopathy associated with Alzheimer's disease (AD) and frontotemporal lobar degeneration with tau pathology (FTLD-TAU). The research will deliver...
- Federal Grant Award Summary Ohio University received a $567,256 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion by January 31, 2029. The award funds research into the mechanisms of activity-dependent tau release and its role in Alzheimer's disease (AD) pathogenesis. The project investigates how neuronal hyperexcitability drives the release of tau protein into the extracellular space, where it...
- Federal Project Grant Award Summary Case Western Reserve University, operating through its Office of Research Administration in affiliation with University Hospitals of Cleveland, received a $161,000 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) on June 15, 2025, with a completion date of May 31, 2027. The award funds scientific research investigating the role of METTL14-mediated RNA N6-methyladenosine (m6A) modification in tau protein...
- Federal Grant Award Summary The Ohio State University received a $657,000 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. The award funds research directed at understanding the molecular mechanisms underlying selective neuronal vulnerability to tau protein aggregation in Alzheimer's disease (AD). Specifically, the project investigates the role of wolframin (WFS1), an endoplasmic...
- Federal Project Grant Award Summary Case Western Reserve University received a $442,750 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective May 15, 2025, with a completion date of April 30, 2027. The research focuses on developing synthetic replicas of tau-dependent protein 43 (TDP-43) filaments associated with frontotemporal dementia and related neurodegenerative diseases. The primary deliverables include an experimental model...
- Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a Project Grant of $188,313 to the University of Tennessee Health Science Center (UTHSC) on September 26, 2025, under the Alcohol Research Programs (CFDA 93.273) to support a two-year research initiative running through August 31, 2027. The project investigates the synergistic effects of developmental and adult ethanol exposure on Alzheimer's disease-related phenotypes using 5XFAD transgenic...
- Federal Grant Award Summary Case Western Reserve University received a $692K Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded March 15, 2026, with completion targeted for November 30, 2030. The project investigates cellular and biochemical mechanisms that modify tau seed propagation across a spectrum of neurodegenerative diseases, including Alzheimer's disease, frontotemporal lobar degeneration, and primary age-related tauopathy....
- Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a $161,000 Project Grant under the Alcohol Research Programs (CFDA 93.273) effective September 15, 2025, with a completion date of August 31, 2027. This grant funds mechanistic research investigating the metabolic basis of sarcopenia (skeletal muscle loss) in alcohol-related liver disease (ALD). The research employs...
- Federal Project Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded The Ohio State University a Project Grant of $474,223 on May 11, 2026, to support research into the mechanisms and neuroprotective targets in alcohol-induced brain injury. The five-year project, scheduled for completion by January 31, 2031, will elucidate brain region- and cell-specific mechanisms underlying alcohol-induced developmental neurotoxicity (AIDN) and develop precision...
- Federal Project Grant Award Summary Award Details: The National Institute on Aging (NIA) awarded a $657,222 Project Grant to Emory University (Office of Sponsored Programs) effective February 15, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). The research will be conducted in Atlanta, Georgia. Project Scope: The award funds research on "Defining Pathological Roles of Novel Protein Interactions with Amyloid in Alzheimer's Disease," which investigates the...
Northeast Ohio Medical University (Neomed) received a $439,865 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 30, 2025, with completion targeted for August 31, 2027. The grant funds biomedical research investigating acetylation changes in alcoholic Alzheimer's disease using mouse models. The research employs stable isotope-based flux studies, pharmacological techniques, and molecular biology approaches to examine how alcohol exposure disrupts brain histone and tau acetylation, potentially accelerating tauopathy and cognitive decline. The project utilizes the hTau mouse model—an amyloid-beta independent model of tauopathy—to study the mechanisms by which alcohol may worsen Alzheimer's disease through impaired glucose metabolism and NAD+ depletion. The primary research deliverables include investigations into alcohol-induced disruptions in histone acetylation dynamics using isotope tracing techniques (13C-glucose and ethanol), assessments of histone deacetylase inhibitor interventions, chromatin immunoprecipitation assays to identify transcriptional regulatory mechanisms, and measurements of acetylation-dependent protein turnover. Kent State University serves as a sub-grantee, providing ChIP-seq (Chromatin Immunoprecipitation sequencing) analysis and quantitative real-time PCR services to identify acetylation-regulated genes involved in learning and memory formation, with responsibilities including experimental design, sequence mapping, peak calling analysis, and quality assessment using established bioinformatics protocols and public databases.Federal Project Grant Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $439.9k | 9/27/25 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
G0642A01S | Kent State University | Project Grant R21AG091377 | $32.3k | 1/22/26 |