Project Grant R21AG091327

Award Date 11/15/24
Completion Date 10/31/26
Dollars Obligated $443K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
San Francisco, CA 94143, USA
Similar Awards
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $258,498.00 to the University of California, Los Angeles (UCLA) to investigate the biological pathways linking sleep health to Alzheimer's disease and cognitive decline. The key objectives are to: Use a multi-omics approach to analyze methylation and metabolomics data associated with short sleep and insomnia among a high-risk Hispanic population, and compare the results to Alzheimer's...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $423,500 to The Leland Stanford Junior University to conduct research on the neurobiological mechanisms underlying attention and memory processes, and how they are altered in human aging. The 2-year project will examine behavioral, electrophysiological, and pupillometry-based rhythms of feature-based attention and episodic memory encoding in a well-powered sample of 150 young and cognitively...
The National Science Foundation awarded a $457,860 Social, Behavioral, and Economic Sciences Project Grant (CFDA 47.075) to the University of California, Irvine to conduct research on memory consolidation over multiple nights of sleep. The 5-year project, starting on May 1, 2025, will use behavioral, physiological, and computational methods to examine how memory benefits change over time and with multiple nights of sleep, with a focus on the weakest memories that are most reliant on sleep...
This $850,000 Project Grant award, funded jointly by the National Science Foundation's (NSF) Division of Integrative Organismal Systems and Division of Information and Intelligent Systems under CFDA 47.070 Computer and Information Science and Engineering, supports research to understand how sleep and memory are connected in the brain. The project will use long-duration, high-resolution recordings of neuronal activity to observe changes in synaptic connections during sleep and memory tasks,...
This $131,085 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University supports research to investigate the use of afternoon phototherapy as a stepped care approach to reduce sleep-wake fragmentation and improve cognition in older adults with mild cognitive impairment. The key objectives are to: 1) apply machine learning techniques to identify factors contributing to sleep-wake fragmentation and cognitive decline, 2) conduct...
This federal Project Grant award of $307,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct a single, highly powered study to identify memory processes that are most sensitive to the asymptomatic, preclinical stage of Alzheimer's disease (AD) pathology. The study combines a continuous report item-location associative memory task with advanced behavioral and neural modeling to estimate subtle changes in memory precision that may differentiate healthy...
The National Science Foundation awarded a $332,602 Project Grant to the University of Texas at Austin under the Social, Behavioral, and Economic Sciences federal grant program (CFDA 47.075). The award will support research from October 2021 through September 2022 to study the relationship between habitual sleep quality, neural activity in episodic memory networks, and episodic memory performance across the adult lifespan. A diverse sample of 90 young, middle-aged, and older adults without...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate memory reactivation during sleep in a mouse model of Alzheimer's disease (AD). The $132,705 award, spanning from September 1, 2024 to August 31, 2026, will enable the Icahn School of Medicine at Mount Sinai to use two-photon microscopy and electrophysiology to measure brain activity across wake and sleep states in AD model mice. The research aims to determine if...
This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research into the molecular interplay of sleep and neurodegeneration using the Drosophila model system. With $2.14 million provided over 11 months, the Trustees of the University of Pennsylvania will investigate how expression of the TDP-43 protein linked to neurodegenerative diseases disrupts sleep in fruit flies. Researchers will aim to define the specific glial subtypes...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,498,158 to Synaptic Health LLC to develop a novel closed-loop feedback neuromodulation system to improve slow wave sleep in Alzheimer's disease patients. The goal of this Phase I project is to create a testable prototype that can sense sleep architecture and provide peripheral neuromodulation stimulation to individuals over 65, a high-risk group for Alzheimer's disease. Successful...

This federal Project Grant award of $442,938, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research at the University of California, San Francisco (UCSF) to investigate the relationship between sleep, memory, and aging.

The key objectives are to: 1) characterize how aging affects sleep patterns required for memory consolidation and synaptic plasticity during long-term memory formation; and 2) determine how upregulating the unfolded protein response can restore sleep-dependent long-term memory formation in aged animals. UCSF has a sub-award with San Jose State University Research Foundation to contribute specific research tasks, including generating fluorescent markers to label synapses and imaging synaptic structures in different genetic models. This research aims to elucidate the mechanisms underlying age-related memory decline and identify potential therapeutic approaches.

Generated 8/5/25, 3:00 AM