This federal Project Grant award of $442,938, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research at the University of California, San Francisco (UCSF) to investigate the relationship between sleep, memory, and aging. The key objectives are to: 1) characterize how aging affects sleep patterns required for memory consolidation and synaptic plasticity during long-term memory formation; and 2) determine how upregulating the unfolded protein response can...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $258,498.00 to the University of California, Los Angeles (UCLA) to investigate the biological pathways linking sleep health to Alzheimer's disease and cognitive decline. The key objectives are to: Use a multi-omics approach to analyze methylation and metabolomics data associated with short sleep and insomnia among a high-risk Hispanic population, and compare the results to Alzheimer's...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $383,400 to Dr. Minjee Kim at Northwestern University to investigate the role of sleep disturbance as a potentially modifiable determinant of cognitive impairment and Alzheimer's disease. The award will fund Dr. Kim's research to: 1) examine associations between sleep disturbance, cognitive function, self-care capacity, and health status in middle-aged adults; 2) develop sleep disturbance...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $423,500 to The Leland Stanford Junior University to conduct research on the neurobiological mechanisms underlying attention and memory processes, and how they are altered in human aging. The 2-year project will examine behavioral, electrophysiological, and pupillometry-based rhythms of feature-based attention and episodic memory encoding in a well-powered sample of 150 young and cognitively...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,498,158 to Synaptic Health LLC to develop a novel closed-loop feedback neuromodulation system to improve slow wave sleep in Alzheimer's disease patients. The goal of this Phase I project is to create a testable prototype that can sense sleep architecture and provide peripheral neuromodulation stimulation to individuals over 65, a high-risk group for Alzheimer's disease. Successful...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $684,924 to Northwestern University to conduct research on the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia. The project aims to systematically characterize central and peripheral measures of the NA system and assess their association with sleep quality and cognitive performance in older adults with insomnia, as well as...
The National Institute on Aging (NIA) awarded a $537,000 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Brigham & Women's Hospital Inc. (a subsidiary of Partners Healthcare System Incorporated) to culturally adapt and pilot a social network approach to deliver a sleep health and mindfulness program to cognitively unimpaired older adults in low-income housing in Boston. The project aims to improve sleep, quality of life, and cognitive function in this...
The U.S. National Institute on Aging (NIA) awarded a $134,000 project grant under the Aging Research program (CFDA 93.866) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct a pilot study on a digital cognitive behavioral therapy for insomnia (DCBT-I) intervention for older adults undergoing orthopedic surgery. The goal is to evaluate the feasibility and efficacy of this abbreviated DCBT-I protocol in improving sleep and cognitive resilience...
This $1,230,000 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support the development and deployment of closed-loop digital interventions through a remote clinical trials platform. The overarching goal is to leverage technology to facilitate memory and cognitive function and prevent or delay age-related cognitive decline, particularly in older adults at risk of Alzheimer's disease and related dementias. The...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provided $137,342.16 to Stanford University to develop generalizable deep learning networks for dual-tracer amyloid and tau positron emission tomography (PET) and magnetic resonance imaging (MRI) of Alzheimer's disease. Specifically, the university will validate the diagnostic value of convolutional neural networks (CNNs) in actual ultra-low-dose amyloid and...