This $442,938 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research to elucidate changes in sleep, memory, and synaptic plasticity that occur with aging, and identify mechanisms to prevent or reverse age-related memory decline. The primary awardee, The Regents of the University of California, San Francisco (UCSF), will conduct a series of studies in the C. elegans model system to: Characterize how aging affects the sleep patterns...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) to George Mason University aims to investigate changes in cholinergic modulation during aging and its effects on memory function and cognitive decline associated with Alzheimer's disease. The $212,095 award will fund the acquisition of experimental data on neural firing patterns and cholinergic dynamics in the hippocampal CA3 region of young and aged mice performing a spatial memory task. This...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,498,158 to develop a testable prototype for a novel closed-loop feedback neuromodulation system to improve slow wave sleep in Alzheimer's disease patients. The device is intended to promote healthy sleep onset, duration, and sleep stage architecture, including slow wave sleep, to prevent the disease-accelerating impacts of disrupted sleep on Alzheimer's disease progression. The awardee,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $146,922 provides funding to The Trustees of Columbia University in the City of New York to investigate the gene expression changes in hippocampal engram cells that underlie memory deficits in a mouse model of Alzheimer's disease. The research aims to identify the unique transcriptional signatures of engram cells during memory encoding, retrieval, and reactivation, and determine how...
This $258,498 Project Grant award, funded by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research to investigate the biological pathways linking sleep health to Alzheimer's disease and cognitive decline. The key objectives are to: Use a multi-omics approach to analyze methylation and metabolomics data associated with short sleep and insomnia among a high-risk Hispanic population, and compare the results to Alzheimer's disease biomarkers to identify...
This Project Grant award of $500,000 from the National Institute on Aging (CFDA 93.866 Aging Research) supports the development of a multi-target peptide drug called ALZ100 by Alzarrok Bio LLC for the treatment of Alzheimer's disease (AD). The project aims to demonstrate the in vivo efficacy of ALZ100 in inhibiting neuroinflammation and neurodegeneration in an AD mouse model. The key products and services to be delivered include: Infusing wild-type and AD transgenic mouse brains with varying...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $640,000 to Northeastern University to develop and apply new intravital microscopy techniques to study the effects of gamma entrainment, a non-pharmacological neuromodulation technique, on cerebral energy metabolism and microvascular hemodynamics in Alzheimer's disease models. The overarching goal is to gain a deeper understanding of how this gamma entrainment method influences brain function,...
This $1,955,041 Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into the relationship between sleep, pericytes, and Alzheimer's disease pathology. The Medical University of South Carolina will investigate whether pericytes, cells that regulate cerebral blood flow and blood-brain barrier permeability, mediate the effects of sleep disruption on Alzheimer's disease progression. Specifically, the...
This federal Project Grant award, valued at $6,226,692.00 and funded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to investigate the role of neuronal hyperexcitability and proteostasis in the progression of Alzheimer's disease (AD). The study aims to track early electrophysiological changes in the locus coeruleus (LC) and hippocampus (HPC) as key brain regions impacted by the accumulation of beta-amyloid and tau proteins. The research seeks to understand...
This $307,000 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a study to identify the earliest memory changes associated with preclinical Alzheimer's disease (AD). The University of Arizona will conduct this research over a 2-year period from September 2024 to August 2026. The key objectives are to use advanced behavioral and neuroimaging techniques to detect subtle changes in memory precision that can differentiate healthy aging...