The National Institute on Aging (NIA) awarded a $688,419 Project Grant under CFDA 93.866 (Aging Research) to The Research Foundation For The State University Of New York, doing business as Stony Brook University. The grant, titled "ACTIVITY-DEPENDENT ASTROCYTE GLUCOSE DYNAMICS REGULATE HIPPOCAMPAL NEUROGENESIS", will support a 5-year research project to investigate the interplay between neuronal activity, astrocyte metabolism, and lactate production, and how these factors regulate the survival of newly generated neurons in the adult hippocampus. The project aims to pinpoint the specific hippocampal interneurons that control astrocyte glucose uptake and metabolism, determine the mechanisms by which lactate supports newborn neuron survival, and analyze potential defects in astrocyte lactate dynamics and associated metabolic enzymes in the context of Alzheimer's disease. The findings are expected to provide new insights into the underlying mechanisms of activity-induced adult neurogenesis and offer potential therapeutic development opportunities for neurodegenerative disorders.
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