The federal Project Grant award R21AG085888 from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $239,338 to the University of Alabama at Birmingham (UAB) to investigate the role of tRNA-derived short and long RNAs in the aging process. The project aims to determine if tRNA halves and extended tRNA transcripts contribute to lifespan or proteostasis changes associated with aging. UAB is collaborating with the University of Virginia on this exploratory research,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,434,563 to The University of Texas Health Science Center at San Antonio to study the role of paracrine growth factor signaling in thymus function and age-associated dysfunction. The research aims to understand the mechanisms regulating thymic epithelial cells, which are critical for T cell development, and how they are impacted by aging. The findings will inform the design of therapeutic...
This Project Grant award of $351,750 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the role of the protein NLRX1 in altering T cell immunity during the aging process. The key objectives are to: 1) elucidate how NLRX1 deficiency affects T cell characteristics related to immune aging; 2) determine the implications of mitochondrial reactive oxygen species and NAD+ in inducing T cell immunity changes via mTOR activity in NLRX1 knockout mice; and 3)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $121,621 to the University of California, Los Angeles (UCLA) to study the role of interleukin-6 signaling on T cell production in aged hematopoietic stem cells and thymic progenitors. The key objectives are to determine the impact of age on T cell development using an in vitro artificial thymic organoid system, and to evaluate the effects of a specific interleukin-6 signaling pathway on...
The National Institute on Aging (NIA) awarded a $331,187 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Brandeis University. The 4-year award, effective September 1, 2024, will support research to understand the role of retrotransposon activity as a potential driver of aging and age-associated diseases. Using the Drosophila model system, the project aims to characterize how increased transposition may contribute to the physiological decline associated with aging....
This $437,366 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the University of Louisville to understand the impact of metabolic changes on stem cell niche homeostasis and function. The study aims to determine if suppressing age-related activation of lipid metabolism pathways (TOR and SREBP) in niche cells can prevent the decline in niche cell maintenance and function. Additionally, the project will characterize the mechanism...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $660,908 to Brandeis University to conduct research on the functions of circular RNAs (circRNAs) in aging. The key objectives are to: Determine the mechanisms by which certain circRNAs promote aging processes. Examine the extent and requirements for circRNA translation and its relationship to aging. Define the connection between the FOXO regulatory network and circRNAs in the context of aging....
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $485,375 to the University of Washington to conduct research on alternative splicing and transposable element expression in aging skeletal muscle. The project aims to discover genomic alterations associated with muscle aging, with the long-term goal of understanding mechanisms to prevent or slow age-related decline in muscle function. Key research activities include...
This federal Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to investigate the role of senescent cells in brain aging and Alzheimer's disease and related dementias (ADRD). The $654,238 award, effective from September 15, 2024 to June 30, 2026, will enable researchers from the University of Texas Health Science Center at San Antonio (UTHSCSA) to generate spatial omics data from ADRD brains and mouse models,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $105,952.00 to support research on the identification and characterization of clonal expansions in aging and aging-related diseases. The project aims to (1) develop tools to identify candidate somatic variants at scale from publicly available data, and (2) apply novel technologies that map genotypes to epigenetic phenotypes in single cells to analyze multiple tissues from aging...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Toledo Health Science Campus Division provides $430,603.00 in funding over a 2-year period from November 15, 2024 to October 31, 2026. The project aims to elucidate the mechanisms by which age-associated changes in transfer RNA (tRNA) modifications affect tRNA cleavage and contribute to cellular senescence. Key objectives include examining tRNA and tRNA-derived fragment modification levels in aged tissues, evaluating tRNA modifications in in vitro models of senescence, and building molecular models to understand how age-related tRNA modification aberrations influence the aging process. This research seeks to provide insights into novel molecular targets for future therapies addressing age-related diseases.