Project Grant R01AG086271

Award Date 8/15/24
Completion Date 4/30/29
Dollars Obligated $2.4M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
San Antonio, TX 78229, USA
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This $428,397 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a multi-year research study on the anatomical and functional characteristics of the thymus in the elderly human population. The research team at the University of Pikeville will conduct qualitative and quantitative assessments of thymic structure and function in cadaver samples, using techniques such as immunohistochemistry and molecular biology to determine the degree of thymic...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $351,750 to Yale University to investigate the role of the protein NLRX1 in age-related changes to the immune system, particularly T cell function. The 5-year project aims to elucidate how decreases in NLRX1 may contribute to the expansion of memory T cells, decreased naive T cell survival, and other age-associated T cell alterations. The research will explore the mechanisms by which NLRX1...
This $451,000 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research by The University of Texas Southwestern Medical Center to investigate the role of the p38 MAPK signaling pathway in regulating lysosome function and tissue integrity during development and aging. The key goals of this 2-year project are to: 1) define the p38 MAPK interactome required for lysosome regeneration, 2) reveal tissue and stage-specific functions of p38 MAPK...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to unravel the molecular mechanisms underlying the cellular rejuvenation process induced by partial reprogramming using the OSKM transcription factors. The $422,419 award will support research to 1) map the transcriptomic, chromatin, and epigenetic changes during OSKM-mediated partial reprogramming, and 2) identify the gene regulatory networks and key regulators...
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This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), is funding research to investigate the role of paracrine growth factor signaling in thymus function and age-associated dysfunction. The $2,414,024 award to the University of Texas Health Science Center at San Antonio aims to combine genetic models and advanced imaging analysis to manipulate FGF21, mTOR, and autophagy pathways in order to understand their regulatory relationships and impact on cortical thymic epithelial cell (cTEC) size, morphology, and overall thymus function. The findings from this 5-year project will inform the development of combination therapeutic strategies to regenerate the aged thymus and improve T cell responses to viral challenges.

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