The federal Project Grant award R21AG086723 for $466,125.00 was granted by the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine to characterize age-related changes in the testis stem cell niche. The key objectives are to: (1) identify genes differentially expressed in young and aged testis niche cells and those dependent on activin signaling, and (2) develop new tools to monitor activin and follistatin proteins and pathway activity in the fly...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $484,625 to The Washington University to conduct research on the spatiotemporal regulation of organelle interactions and lipid metabolism. The award aims to biophysically and structurally define how lipolytic complexes are assembled and regulated on the surface of lipid droplets, as well as to examine how disruption of lipid droplet...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $153,512.00 to the Regents of the University of Minnesota to conduct research on the relationship between lipid metabolism, mitochondrial stress, and cellular senescence. The key objectives are to: 1) use proteomics to characterize mitochondrial protein targets of carbonylation during obesity and aging, and 2) investigate the role of mitochondrial stress and signaling on adipose tissue...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $381,022 to Emory University to investigate how a highly conserved protein, RhoGAP15B, coordinates signaling pathways involved in stem cell renewal within the intestinal tissue of Drosophila (fruit flies). The overarching goal is to leverage the strength of the researchers' preliminary data to understand how this protein regulates cell division and tissue repair mechanisms, which have...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will support research by Tufts University School of Medicine to develop metabolomics clocks as a tool to explore the mechanisms of aging. The total funding amount is $592,507 and the award period runs from Sep 30, 2024 to Jun 30, 2029. The key objectives of the project are to: 1) develop sex- and tissue-specific metabolome clocks in the Drosophila model system that can...
This $453,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to define the molecular mechanisms and cellular dynamics required to assemble a functional stem cell niche during embryonic development. The research, conducted at East Carolina University, aims to elucidate the signaling pathways, transcriptional regulators, and cytoskeletal processes that guide the migration and...
This Project Grant award of $395,796 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research at Brown University to develop genetic, pharmacological, and dietary interventions that delay the onset and progression of age-related diseases. The key objectives are to: 1) Investigate the interconnectedness and hierarchical structure of the hallmarks of aging, such as loss of genomic integrity, activation of retrotransposons, and accumulation of lipid droplets; 2)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $402,500 to Duke University to conduct research on the role of glutamine metabolism in regulating muscle stem cell function. The research aims to: 1) determine if glutamine-driven bidirectional metabolism is necessary for muscle stem cell function and myogenesis, 2) investigate how glutamine metabolism is impaired in aged muscle stem cells and whether restoring this pathway can reverse age-related...
This $451,000 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research by The University of Texas Southwestern Medical Center to investigate the role of the p38 MAPK signaling pathway in regulating lysosome function and tissue integrity during development and aging. The key goals of this 2-year project are to: 1) define the p38 MAPK interactome required for lysosome regeneration, 2) reveal tissue and stage-specific functions of p38 MAPK...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $378,750 in funding to Saint Louis University to conduct research on the role of cytosolic DNA-induced sterile inflammation in driving cellular and organismal progeria/aging hallmarks. The key objectives are to: 1) define the non-canonical mode of STING stimulation upon progerin-induced accumulation of cytosolic DNA, 2) examine how STING, STAT1, and downstream interferon-stimulated genes like...