The University of Rochester received a $423,500 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) to investigate the role of mitochondrial dysfunction and oxidative stress in the progression of tau pathology in Alzheimer's disease. The two-year project will utilize novel optogenetic tools to spatiotemporally control mitochondrial function and reactive oxygen species production in both ex vivo brain slice cultures and an in vivo mouse model of tau...
This federal Project Grant award of $1,118,700.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine will support research to elucidate the role of pathological tau protein in disrupting endosomal microautophagy (EMI), a critical protein degradation pathway affected in Alzheimer's disease. The research aims to determine which components of the EMI pathway are most vulnerable to tau pathology and whether restoring EMI function can...
The National Institute on Aging (NIA) awarded a $763,922 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The Leland Stanford Junior University. The 5-year grant, with a start date of June 1, 2025 and an end date of April 30, 2030, will fund research to investigate the mechanism by which abnormal tau protein interacts with mitochondrial dysfunction and contributes to the development of age-related neurodegenerative diseases like Alzheimer's, Parkinson's, and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $752,525 to Rutgers, The State University to examine the role of the microtubule network in a mouse model of Alzheimer's disease. The key objectives are to study how activity-dependent changes in microtubule stability and the microtubule-binding protein stathmin affect synaptic localization of the GLUA2 subunit and memory deficits in a tau-related Alzheimer's disease model. The research aims...
The National Institute on Aging (NIA) awarded a $773,816 Project Grant (CFDA 93.866 - Aging Research) to the University of California, Irvine to conduct a comprehensive study on the molecular mechanisms underlying aberrant protein accumulation in Alzheimer's disease-related tauopathies. The project aims to generate cell-type-specific atlases of misprocessed RNAs and proteins in mouse models and human brain tissues to identify new pathways and protein interaction networks involved in...
This federal Project Grant award of $2,895,962 from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research to investigate how a microRNA, miR-129-2, may protect against tau accumulation and neurodegeneration in Alzheimer's disease. The project, conducted by Trustees of Boston University, aims to map the expression of miR-129-2 in the entorhinal cortex across mouse and human samples, examine how miR-129-2 regulates Alzheimer's disease-relevant genes and pathways,...
This federal Project Grant award of $816,661 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research initiative by the Regents of the University of California, San Francisco (UCSF) to comprehensively map the impact of tau pathology on the proteome, which is expected to be mediated in part through disruptions in mRNA splicing. The research leverages AD mouse models and human iPSC tauopathy models to discover protein drivers of tauopathy and validate such drivers in...
This Project Grant award from the National Institute on Aging, under the Aging Research federal grant program (CFDA 93.866), provides $308,000.00 to the Regents of the University of Minnesota to investigate the impact of amyloid-beta 42 (Aβ42) on mitochondrial ribonucleoprotein granule dynamics and utilize optogenetic control of Aβ42 and mitochondrial ribonucleoprotein granules in mitochondria. The overarching goal is to identify the mechanisms by which Aβ42 interferes with mitochondrial...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate how Alzheimer's disease (AD) pathogenesis interferes with synaptic autophagy and whether targeting synaptic autophagy can be neuroprotective in an AD mouse model. The $628,000 award to Rutgers, The State University of New Jersey will fund research to: 1) determine which step in the autophagic processing of synaptic proteins is disrupted by AD-associated changes using primary...
The National Institutes of Health's National Institute on Aging awarded $3.468 million to The Trustees of Columbia University under the Aging Research grant program (CFDA 93.866) for the period September 15, 2022 through August 31, 2025. The project aims to investigate the role of PTEN-induced putative kinase 1 (PINK1) in abnormal tau accumulation and related mitochondrial dysfunction and neuroinflammation in Alzheimer's disease and related tauopathies. Specifically, the university researchers...