This federal Project Grant award for $729,567, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), will fund a study to investigate the causal impacts of two key childhood environmental conditions - school quality and infectious disease exposure - on adult health and mortality outcomes. The study aims to construct a novel dataset linking individual-level childhood environment factors to longevity, in order to examine how these modifiable conditions affect schooling,...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $2,251,070 to the University of California Irvine through July 2025. The grant supports research to develop new statistical methodologies for analyzing Alzheimer's disease data from longitudinal cohort studies. Key deliverables include methods for assessing prediction precision for recurrent event survival data using time-dependent ROC and C-index...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under CFDA Program 93.865 "Child Health and Human Development Extramural Research", provides $1,936,773 to The Leland Stanford Junior University to construct a new database linking administrative birth and death data for 10 to 25 year olds with demographic, educational, familial, and health insurance information. The goal is to document trends and inequalities in...
This Project Grant award of $1,734,497.00 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), will fund a comprehensive study of the mortality experience of the U.S. foreign-born population. The University of Texas Medical Branch at Galveston (UTMB) will conduct the research, which aims to: 1) provide the first set of country and world region-specific life expectancies for the foreign born, 2) test the role of earnings trajectories on...
This Project Grant awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), provides $366,648 to develop statistical methods for accurate estimation and prediction in Alzheimer's disease (AD) research. The key products and services to be delivered include: Methods for estimation and regression that enable the use of clinically relevant time origins in longitudinal cohort studies, while properly adjusting for complex truncation and censoring....
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $122,858 to Harvard T.H. Chan School of Public Health to conduct research on molecular profiles associated with mortality risk and longevity. The 2-year project aims to utilize plasma metabolomic and proteomic data to investigate the relationship between genes, proteins, metabolites, and all-cause mortality. Key objectives include determining genetic factors influencing a...
The National Institute on Aging (NIA) awarded a Project Grant (CFDA 93.866 - Aging Research) totaling $455,274 to The Johns Hopkins University to develop and apply statistical methods to improve scientific inferences in Alzheimer's disease (AD) research. The key objectives are to: Handle age-specific prevalent cases in case-control studies to address survivor bias, Develop regression methods for analyzing age at biomarker positivity and remaining time to onset of clinical symptoms, and Create...
This Project Grant award of $372,690 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to discover the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The project will develop new statistical methods to uncover how amyloid-beta, tau accumulation, and cognition are causally related in different AD subpopulations. The goal is to reveal optimal treatment windows and target groups for therapies that reduce amyloid-beta or...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) is providing $2,331,210 to the University of Maryland, Baltimore to develop novel analytical methods to better understand and predict post-fracture recovery trajectories in older adults living with Alzheimer's disease and related dementias (ADRD). The key products and services to be delivered include: Novel machine learning-assisted methods to identify unique patient characteristics...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under CFDA 93.865 Child Health and Human Development Extramural Research, aims to identify and characterize "mortality hotspots" in low- and middle-income countries where child or adult mortality rates remain exceptionally high. The $231,000 award to The Leland Stanford Junior University will fund a 2-year project to: 1) obtain spatially granular estimates of...