This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $109,595.00 to the University of California, Davis to conduct comprehensive microscopic studies on a novel rhesus monkey model of Alzheimer's disease. The research aims to determine the regional and laminar patterns of tau-based neuropathology, neuronal loss, synaptic health, and neural circuit functionality within the entorhinal cortex, hippocampus, and neocortex of the monkey brain. These...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $146,922.00 to The Trustees of Columbia University in the City of New York to conduct research on the impact of Alzheimer's disease on genetic signatures of hippocampal memory traces. The research project will use cutting-edge techniques like single-nuclear RNA sequencing to compare the gene expression profiles of engram cells (cells that store memories) in normal mice versus a mouse model of...
This $1,758,779 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the Winifred Masterson Burke Medical Research Institute to assess neuronal vulnerability in the entorhinal cortex due to Alzheimer's disease pathology. The key objectives are to determine whether hyperexcitability in Alzheimer's disease is caused by dysfunction of excitatory or inhibitory neurons in the entorhinal cortex, and to modulate neuronal activities to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $461,146 to Yale University to investigate the dysregulation of cortical astrocytes, a key cell type involved in inflammatory responses and synaptic function, in Alzheimer's disease (AD) models. The research aims to longitudinally track changes in astrocytic and neuromodulatory signaling across the cortex in awake, behaving animals using novel imaging approaches. The goal is to elucidate the...
This federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), provides $6,226,692 to The Trustees of Columbia University in the City of New York to conduct research on the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the progression of Alzheimer's disease. The research aims to identify key early events in Alzheimer's disease pathology, particularly in the locus coeruleus and hippocampus regions of the brain, and...
This Project Grant from the National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $5,006,006 to Yale University to support multimodal imaging research aimed at better understanding Alzheimer's disease pathogenesis and treatment response. Specifically, the award will fund research leveraging positron emission tomography, wide-field calcium imaging, and functional magnetic resonance imaging to map changes in excitatory and inhibitory...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Brown University totals $771,518.10 and runs from September 1, 2024 to May 31, 2029. The project aims to elucidate the role of the protein CHI3L1/YKL-40 in the pathogenesis of Alzheimer's disease (AD). Specifically, the research will: 1) Investigate how CHI3L1 induces neuronal apoptosis and neurodegeneration through interactions with receptors on neurons and microglia, using human stem...
The National Institute on Aging (NIA) awarded a $2,168,393 Project Grant (CFDA 93.866) to Yale University to examine the role of kynurenic acid in age-related cognitive deficits. The 3-year grant, starting September 1, 2023, will study how increased kynurenine inflammatory signaling with aging impairs higher cortical function in the dorsolateral prefrontal cortex (DLPFC) through blockade of NMDAR and α7-nAChR receptors, leading to working memory deficits. The research will test strategies to...
The National Institutes of Health's National Institute on Aging awarded a $4.7 million Project Grant to the University of California, Davis under the Aging Research program (CFDA 93.866) to investigate neuropathogenesis in the interoceptive-allostatic network as part of an animal model of early Alzheimer's disease pathogenesis. The grant will fund detailed neuroimaging and histological analyses of the brain network responsible for generating and regulating affect in rhesus monkeys administered...
This federal Project Grant award for $461,313, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research to investigate the role of the protein CSPα in regulating synaptic autophagy and its implications for neurodegenerative diseases. The research aims to characterize synaptic vesicles, autophagosomes, and related proteins in wild-type, CSPα knockout, and CLN4 (a neurodegenerative disease) models using techniques such as electron microscopy,...