This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $386,900.00 to the University of Texas Health Science Center at Houston (UTHealth) to study the role of the circadian clock and retinoid acid receptor-related orphan receptor (ROR) proteins in regulating metabolic function and healthy aging. The key objectives are to: 1) Evaluate the impact of ROR proteins on healthspan and lifespan using mice with skeletal muscle-specific ROR knockout, 2)...
This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $640,000 to Northeastern University to develop and apply new intravital microscopy techniques to study the effects of gamma entrainment (GENUS) neuromodulation in Alzheimer's disease (AD) models. The project aims to gain a deeper understanding of how GENUS influences cerebral energy metabolism and microvascular hemodynamics in the living brain at cellular resolution. The advanced...
The National Institute on Aging (NIA) awarded a $419,005 Project Grant under the Aging Research program (CFDA 93.866) to Purdue University on May 15, 2025. The grant will support research to investigate how Alzheimer's disease alters one-carbon metabolism and histone methylation, and how these changes may disrupt circadian rhythms and sleep patterns. The project will leverage the Drosophila (fruit fly) model system to identify conserved mechanisms underlying the link between...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $451,250 to support research investigating the molecular mechanisms that coordinate circadian clock gene expression in the brain's central pacemaker and peripheral oscillators. The 5-year project aims to elucidate how internal and external signals, particularly light exposure, are integrated to regulate circadian...
This $4.49 million project grant from the National Institutes of Health's National Institute on Aging will fund research at The Washington University to investigate the relationship between amyloid plaque deposition, cellular metabolic dysfunction, and functional brain organization in Alzheimer's disease (AD) mice models. Over three years, the researchers will use multi-photon fluorescence lifetime imaging microscopy, multi-parametric photoacoustic microscopy, and wide-field optical imaging to...
This $4.46 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866) to develop a new in vivo magnetic resonance imaging biomarker for early detection of Alzheimer's disease neurodegeneration. Specifically, the awardee, Washington University, will utilize quantitative gradient recalled echo MRI techniques to identify two types of hippocampal tissue in preclinical and mild...
The National Institute on Aging, part of the Department of Health and Human Services' National Institutes of Health, awarded $3,724,674 under the Aging Research program (CFDA 93.866) to Texas Tech University Health Sciences Center in Lubbock, Texas. The three-year project grant beginning September 15, 2022 will support research into the impacts of microrna-455-3p (miR-455-3p) in Alzheimer's disease. Specifically, the grantee will investigate the neuroprotective effects of overexpressing and...
This federal Project Grant award, titled "UNTANGLING THE BIDIRECTIONAL RELATIONSHIP BETWEEN THE SPREAD OF PATHOLOGICAL PROTEIN AGGREGATES, SLEEP, AND CIRCADIAN CLOCK DISRUPTION IN NEURODEGENERATIVE DISEASE," is funded by the National Institute on Aging (CFDA 93.866 - Aging Research) for a total of $2,181,132 over the period of Sep 30, 2024 to Jun 30, 2029. The primary objective of this grant is to investigate the mechanisms by which disrupted sleep and circadian timing contribute to...
The National Institute on Aging (NIA) awarded a $790,491 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The University of Texas Health Science Center at San Antonio (UTHSCSA) for the "VASCULAR IMAGING BIOMARKER RELATIONSHIPS TO ALZHEIMER'S DISEASE (VIBRA)" project. The grant aims to create standardized, computerized methods for quantifying cerebral small vessel disease biomarkers on brain MRI scans across diverse Alzheimer's Disease Research Center (ADRC)...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,041,438 to develop new computational tools and biomarkers for Alzheimer's disease. The University of Miami will aggregate and analyze DNA methylation datasets to identify age-associated epigenetic changes related to aging and Alzheimer's progression. Researchers will create a searchable web interface to disseminate findings on the role of DNA...