This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Washington provides $485,375 to investigate the mechanisms underlying reduced resilience and adaptability of aging skeletal muscle. The project aims to determine whether increased mitochondrial redox stress drives the impairment of redox stress response signaling and declining muscle function with age. The researchers will use skeletal muscle contraction as a model to examine the...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,127,548 to the University of Texas Medical Branch at Galveston to investigate the role of post-translational modifications of myosin and its chaperone UNC-45 in the development of sarcopenia, the age-related loss of muscle mass and function. The project aims to use a combination of in vitro biochemical and biophysical assays, as well as in vivo techniques in the C. elegans model organism,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,343,725 to The Spaulding Rehabilitation Hospital Corporation to investigate the effects of muscle aging and activity on extracellular vesicle regulation of muscle regeneration. The primary goals are to: 1) examine how aging of the skeletal muscle extracellular matrix alters the molecular composition of muscle-derived extracellular vesicles and impacts muscle stem cell myogenicity and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to the University of Washington provides $647,672 in funding to conduct research on the mechanisms underlying the reversal of cardiac aging by urolithin A treatment. The project aims to investigate mitochondrial dysfunction in the aging heart, which is thought to be a key contributor to the decline in cardiovascular function with age. The research will focus on understanding how urolithin A, a natural...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,512 to the University of Florida to conduct research on the role of the kynurenine pathway and aryl hydrocarbon receptor (AhR) activation in age-related physical decline and muscle weakness. The 16-month project will use novel genetic mouse models to investigate whether elevated kynurenine levels and increased AhR activity in skeletal muscle are mechanistic drivers of the decline in...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $141,890 to the University of Arkansas to examine the role of the MYC gene in regulating skeletal muscle function, metabolism, and age-related decline. The primary objectives are to: 1) analyze functional, bioenergetic, and cellular changes in skeletal muscle with pulsatile MYC induction and exercise across the lifespan; 2) perform single-cell RNA sequencing and DNA methylation analyses in...
This Project Grant awarded by the National Institute on Aging (NIA) under CFDA 93.866 Aging Research supports research to explore the sex-specific determinants of muscle quality in older adults. The $116,710 award will fund a study at the University of Connecticut to directly measure muscle quality, neurological impairment, muscle adiposity, and muscle stiffness in 60 older adults, comparing 30 males and 30 females. The goal is to identify sex-specific therapeutic targets to improve muscle...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $402,500 to Duke University to conduct research on the role of glutamine metabolism in regulating muscle stem cell function. The research aims to: 1) determine if glutamine-driven bidirectional metabolism is necessary for muscle stem cell function and myogenesis, 2) investigate how glutamine metabolism is impaired in aged muscle stem cells and whether restoring this pathway can reverse age-related...