This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Washington provides $485,375 to investigate the mechanisms underlying reduced resilience and adaptability of aging skeletal muscle. The project aims to determine whether increased mitochondrial redox stress drives the impairment of redox stress response signaling and declining muscle function with age. The researchers will use skeletal muscle contraction as a model to examine the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research to examine the role of the MYC gene in regulating skeletal muscle function, metabolism, and age-related changes. The $141,890 award to the University of Arkansas will support the development of mouse models to investigate how MYC induction and exercise impact muscle at the cellular and molecular levels, including DNA methylation "clock" age. The research aims to provide...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the cellular and molecular mechanisms underlying motor unit expansion, a key compensatory process that preserves muscle function during aging and denervation. The $1,130,661 award, effective from September 20, 2024 to May 31, 2029, supports research conducted by the Regents of the University of Michigan to: (1) establish how aging affects the Schwann cell signaling pathways that drive...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $402,500 to Duke University to conduct research on the role of glutamine metabolism in regulating muscle stem cell function. The research aims to: 1) determine if glutamine-driven bidirectional metabolism is necessary for muscle stem cell function and myogenesis, 2) investigate how glutamine metabolism is impaired in aged muscle stem cells and whether restoring this pathway can reverse age-related...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $270,114 to the Oklahoma Medical Research Foundation (OMRF) to investigate the role of transcription factor EB (TFEB) in maintaining skeletal muscle function and recovery with aging. The goal is to determine if TFEB serves as a critical node for improving proteostatic maintenance and muscle function in conditions of sarcopenia and disuse atrophy in aged mice. The research plan includes specific...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $196,460 to Rockefeller University to conduct research on the structural and functional characterization of the mRNA export platform in S. cerevisiae. The goal is to generate a high-resolution integrative model of the mRNA export platform and understand how aging-associated mutations disrupt its assembly and impact gene regulation, leading to aging phenotypes. The research will leverage...
This Project Grant award of $387,006 from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to understand how indoles derived from commensal gut bacteria can promote mobility and counteract sarcopenia (age-related muscle wasting) in aging animals. The research aims to determine the mechanisms by which indoles regulate muscle protein homeostasis, mitochondrial function, and other cellular pathways to maintain muscle mass and function during...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $576,893.00 to the University of Texas Medical Branch at Galveston to investigate the role of post-translational modifications (PTMs) of the muscle proteins myosin and its chaperone UNC-45 in age-related muscle loss, or sarcopenia. The researchers will use a combination of in vitro biochemical, biophysical, and in vivo techniques with the C. elegans model organism to test their hypothesis that...