This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $135,057 to the Oklahoma Medical Research Foundation (OMRF) to investigate the role of the transcription factor TFEB as a critical regulator of proteostasis and skeletal muscle function in aging. Specifically, the project aims to determine if increasing TFEB activity can improve the maintenance and recovery of muscle mass and function in aged mice, both in the context of sarcopenia and disuse atrophy. The research will employ state-of-the-art genetic, molecular, and physiological techniques, including work with mouse and fruit fly models, to advance the understanding of how compromised autophagy and proteostasis contribute to age-related muscle dysfunction. Successful outcomes could identify TFEB as a novel therapeutic target to protect against sarcopenia and improve recovery from disuse atrophy in the elderly.
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