This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $654,238 to The University of Texas Health Science Center at San Antonio to study the role of senescent cells in Alzheimer's disease and related dementias (ADRD). The primary goals are to: Identify molecular markers and changes in the microenvironment of senescent neurons compared to healthy neurons, with a focus on their contribution to neuronal death in brain aging and ADRD (R21 phase). Use...
The National Institute on Aging (NIA) awarded a 5-year, $1,648,493 Project Grant (CFDA 93.866) to the Icahn School of Medicine at Mount Sinai to systematically investigate the molecular mechanisms of brain senescence in different molecular subtypes of Alzheimer's disease (AD). The project aims to identify and characterize senescent cells in major AD subtypes using advanced multi-omics and spatial transcriptomics techniques. The research team, which includes experts in translational senescence...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
The University of Massachusetts Medical School (UMass Medical) was awarded a $1,507,500 Project Grant from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to conduct a study on spatial single-cell analysis of somatic mutations in the human brain during aging and neurodegeneration. The goal is to develop and apply new single-cell whole-genome sequencing methods to study somatic mutations in neurons from late-stage Alzheimer's disease and...
This $614,424 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to better understand the role of microglia, the brain's immune cells, in the development of Alzheimer's disease (AD). The University of Washington (UW) will leverage novel explainable AI techniques and human induced pluripotent stem cell (iPSC) models to uncover subtle microglial changes that occur early in AD progression. Specifically, UW will expose microglia-neuron iPSC cultures to...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This Project Grant award from the National Institute on Aging (NIA, CFDA 93.866 Aging Research) provides $147,486 to Albert Einstein College of Medicine to study the role of chaperone-mediated autophagy (CMA) in cellular senescence and aging. The research aims to understand: 1) how CMA activity changes upon induction of senescence, 2) if CMA modulates the kinetics of senescence and by what mechanisms, 3) if CMA is required for clearance of senescent cells by the immune system, and 4) if...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $663,376 to The Regents of the University of California, San Francisco to explore the molecular mechanisms underlying the heterogeneity of Alzheimer's disease and related dementias. The project aims to identify key genes that mediate the selective vulnerability of brain regions to distinct pathological protein conformers, such as tau and alpha-synuclein, using a novel computational modeling...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $794,341 to the University of Illinois to conduct research on the role of pathogen-induced cellular senescence and blood-brain barrier dysfunction in the development and progression of Alzheimer's disease. The 5-year project aims to leverage experimental mouse models, molecular characterization of endogenous retroviruses, and human induced pluripotent stem cell models to investigate...
This $489,500 Project Grant awarded by the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research at Tufts Medical Center on the role of the CDK6 protein in Alzheimer's disease (AD). The key objectives are to 1) define the types of senescent cells in the hippocampus and entorhinal cortex of mouse models lacking CDK6 or with altered CDK6 kinase activity, and 2) determine the molecular mechanisms by which CDK6 affects cellular senescence, neural stem cell...