This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
This $654,238 Project Grant award from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to investigate the role of senescent cells in brain aging and the development of Alzheimer's disease and related dementias (ADRD). The project aims to generate high-resolution spatial omics data from ADRD brains and mouse models to identify molecular changes in the microenvironment of senescent neurons compared to healthy neurons. The work will be conducted by...
The National Institute on Aging (NIA) awarded a $125,896 Project Grant under the Aging Research program (CFDA 93.866) to The Washington University in St. Louis to conduct research on Alzheimer's disease (AD) risk and resilience pathways. The project aims to perform deep molecular characterization of AD genetic risk factors and protective mechanisms using state-of-the-art single-cell multi-omic analyses of healthy and AD human brain tissue, as well as transgenic AD mouse models. Key objectives...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine provides $254,250 to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The goal is to create a brain microstructure age framework that provides insights into the processes underlying brain aging and Alzheimer's disease/related dementias (AD/ADRD). The award period runs from Sep 15, 2024 to Jun...
This $871,093 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Sloan-Kettering Institute for Cancer Research supports research to elucidate the mechanisms underlying the regulation of the transcription factor TFEB and the autophagy-lysosomal pathway, and to investigate their therapeutic potential as treatments for Alzheimer's disease. The key objectives are to study how the protein phosphatases CDC25A and PP2A regulate TFEB signaling and the...
This $343,440 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports a research study by Dr. Lolita Nidadavolu at the Johns Hopkins University School of Medicine. The study aims to examine the association between cell-free DNA and microglial activation in Alzheimer's disease. Specifically, the project will analyze serum samples to assess the relationship between cell-free DNA levels and microglial activation markers (Aim 1). It will also...
This federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to understand how advancing age contributes to the occurrence and progression of Alzheimer's disease (AD). The award, totaling $1,055,595.00 from July 2024 to April 2026, will support research at Colorado State University to determine how increasing endosome formation, a key cellular process, can decrease tau protein accumulation in neurons and influence cognition and AD pathology...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the cell-type specific impacts of Alzheimer's disease (AD) pathology within the medial temporal lobe. The $103,304 award, effective August 1, 2024 through July 31, 2025, will utilize advanced viral tracing methods and microscopy imaging to identify and reconstruct 3D entorhinal cortex-CA1 neuron circuits that are susceptible to AD pathology propagation. After...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $842,114 to the Icahn School of Medicine at Mount Sinai to systematically investigate the molecular mechanisms of brain senescence in different molecular subtypes of Alzheimer's disease (AD). The project aims to characterize senescent cells in the brains of AD patients using advanced single-cell multi-omic techniques and spatial transcriptomics. The goal is to identify novel therapeutic...
The University of Massachusetts Medical School (UMass Medical) was awarded a $1,507,500 Project Grant from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to conduct a study on spatial single-cell analysis of somatic mutations in the human brain during aging and neurodegeneration. The goal is to develop and apply new single-cell whole-genome sequencing methods to study somatic mutations in neurons from late-stage Alzheimer's disease and...