Project Grant R21AG086778
- This $252,000 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support a study to examine the relationship between menopausal hormone therapy, the gut microbiome, and estrogen-related outcomes in women with HIV. The study, to be conducted by the Albert Einstein College of Medicine, will perform shotgun metagenomic sequencing of gut microbiome samples collected before and after a 12-week randomized, double-blinded,...
- This federal Project Grant award of $451,000.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a research project titled "Estrogen Modulation of Chondrocyte Mechanotransduction via Piezo1 and TRPV4." The project aims to investigate how biological sex and sex hormones, particularly estrogen, modulate the response of chondrocytes (cartilage cells) to mechanical stimulation through the mechanosensitive channels Piezo1 and TRPV4. This research seeks to better...
- This $1.23 million Project Grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases will fund research at Loyola University of Chicago from June 2022 to May 2025 under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to further the university's investigation into how certain species of Lactobacillus bacteria found in the female urinary tract can control colonization of uropathogenic Escherichia coli (UPEC) through...
- This federal Project Grant award, valued at $692,843.00 and provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of estrogen formulation and delivery route on skeletal outcomes in functional hypothalamic amenorrhea (FHA). The primary objectives of this 5-year research project at the University of Virginia are to...
- This federal Project Grant award for $431,750, provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), supports research at the University of California, Irvine (UCI) to investigate the mechanisms of age-related urethral dysfunction and potential anti-fibrogenic therapies. The research aims to evaluate the effect of aging on the female mouse urethra, including functional, morphometric, and transcriptomic analyses. Key areas of focus include...
- This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $3,005,541.00 to Baylor College of Medicine to conduct research on the mechanisms driving age-dependent and sex-dependent changes in bladder immunity that contribute to recurrent urinary tract infections (UTIs) and other lower urinary tract disorders in older women. The...
- This Project Grant award, valued at $126,460 and provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to identify ecological drivers of dysbiosis in the female reproductive tract. The research will use genetically tractable uropathogenic E. coli and specialized animal and tissue culture models to determine how host cell metabolism controls vaginal community composition and perpetuates...
- This $3,400,004 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to investigate the role of waterborne Escherichia coli transmission as a cause of community-acquired urinary tract infections (UTIs). The key objectives are to: (1) model the drivers and dynamics of E. coli contamination in water systems, (2) identify socio-behavioral, epidemiological, genomic, and...
- This Project Grant award of $1,539,469.00 from the Defense Health Agency was provided to the University of Utah under the Military Medical Research and Development program (CFDA 12.420) to conduct research on the "Molecular Crosstalk Between Estrogens and Progestogens in Endometrial Cancer." The award will fund this biomedical research project from September 1, 2023 to August 31, 2026. The University of Utah has an extensive track record of collaborating with government agencies on...
- This federal Project Grant award of $433,125.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate the role of sex hormones in influencing host-microbiome interactions in the human oral mucosa. The award will fund a 5-year project from August 1, 2025 to April 30, 2030, conducted by the University of Massachusetts Lowell. The research aims to develop a mechanistic...
This Project Grant award of $458,616.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports research on "The Impact of Estrogen Hormone Therapy Modality on Urobiome Dynamics in Postmenopausal Women." The grant, awarded to the University of Texas at Dallas (UTD), will investigate how estrogen hormone therapy (EHT) affects the female urogenital microbiome and its potential to reduce recurrent urinary tract infections (rUTIs) in postmenopausal women. The research aims to elucidate why EHT does not promote urogenital Lactobacillus colonization in some women, which is hypothesized to be a key mechanism by which EHT protects against rUTIs. This 2-year project leverages UTD's expertise in biomedical research to address a significant public health challenge, with the goal of developing improved treatment strategies for rUTIs in postmenopausal women.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $458.6k | 9/12/25 |