Project Grant R01HD119174
- This Project Grant award of $170,640 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to investigate the role of the FGFR1 signaling pathway in the intersection between reproduction and metabolism. The primary objectives of this 5-year research project are to: (1) conduct a recall-by-genotype study and in-depth neuroendocrine and metabolic phenotyping in...
- This federal Project Grant award of $1,394,304.00, awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research Program (CFDA 93.865), supports research to understand the relationship between obesity, endometrial hyperplasia, and endometrial cancer risk in women. The project, titled "Understanding Endometrial Tissue Field Defects in Obesity-Related Endometrial Hyperplasia", is a...
- This Project Grant award of $121,887.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to examine the neurobiological mechanisms connecting estradiol flux and anhedonia (lack of pleasure) in perimenopausal women. The key objectives are: 1) to investigate the influence of estradiol flux on striatal dopamine binding using PET imaging, 2) to study the relationship between estradiol flux and neural connectivity during reward...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $298,883 to Iaterion, Inc. to develop a safer menopausal hormone therapy (MHT) formula that can be used long-term to treat protracted menopausal symptoms and prevent chronic diseases like osteoporosis, diabetes, obesity, and metabolic syndrome. The project aims to create an estradiol/reprogramming ligand combination that can potentially replace the progestin component of current MHT...
- This Project Grant award of $458,616.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports research on "The Impact of Estrogen Hormone Therapy Modality on Urobiome Dynamics in Postmenopausal Women." The grant, awarded to the University of Texas at Dallas (UTD), will investigate how estrogen hormone therapy (EHT) affects the female urogenital microbiome and its potential to reduce recurrent urinary tract infections (rUTIs) in...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $233,250 to The Washington University in Missouri to conduct research on the peripheral and central mechanisms of endometriosis pain. The key objectives are to identify the mechanisms underlying endometriosis pain and changes in pain after lesion removal surgery, focusing on...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $301,299 to Burst Diagnostics Inc. to develop a multiplexed, quantitative point-of-care and at-home diagnostic test to measure estradiol, progesterone, luteinizing hormone, and follicle stimulating hormone levels in blood and saliva. The goal is to enable personalization of...
- This Project Grant award of $157,000.00, provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a longitudinal, prospective study investigating the relationship between pregnancy stress, maternal mental health symptoms, sex steroid hormones, and postpartum maternal sensitivity. The study aims to determine the individual and coordinated trajectories...
- This federal Project Grant award of $451,000.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a research project titled "Estrogen Modulation of Chondrocyte Mechanotransduction via Piezo1 and TRPV4." The project aims to investigate how biological sex and sex hormones, particularly estrogen, modulate the response of chondrocytes (cartilage cells) to mechanical stimulation through the mechanosensitive channels Piezo1 and TRPV4. This research seeks to better...
- This Project Grant award, valued at $643,049.00, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports the development of a physiomimetic model of endometrioma, a type of endometriotic lesion, to study processes driving lesion initiation, ovarian stroma invasion, and persistence in a chronic inflammatory environment. The research aims to uncover...
This federal Project Grant award, valued at $692,843.00 and provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of estrogen formulation and delivery route on skeletal outcomes in functional hypothalamic amenorrhea (FHA). The primary objectives of this 5-year research project at the University of Virginia are to examine the impact of different estrogen administration methods, including combined oral contraceptives and transdermal 17β-estradiol with cyclic progesterone, on bone mineral density and other skeletal health measures in adolescents and young women with FHA, including those with anorexia nervosa and exercise-induced amenorrhea. The research aims to identify optimal estrogen treatment approaches to improve long-term bone health in this population.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $692.8k | 8/14/25 |