Project Grant R21AG085324

Award Date 9/16/23
Completion Date 9/15/25
Dollars Obligated $424K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Rochester, NY 14642, USA
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research into the role of mitochondrial deficits in tauopathy-linked autophagy defects. The total funding amount is $431,750.00 and the award period runs from June 1, 2025 to May 31, 2027. The primary objective is to determine the mechanism by which overexpression of the mitochondrial protein MIRO enhances autophagy and alleviates tau pathology in tauopathy neurons. Specifically, the...
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This federal Project Grant award of $1,118,700.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine will support research to elucidate the role of pathological tau protein in disrupting endosomal microautophagy (EMI), a critical protein degradation pathway affected in Alzheimer's disease. The research aims to determine which components of the EMI pathway are most vulnerable to tau pathology and whether restoring EMI function can...
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