Project Grant R21AG084284

Award Date 9/1/23
Completion Date 8/31/25
Dollars Obligated $817K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Birmingham, AL 35294, USA
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This Project Grant award, with a total funding amount of $126,607, was provided by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The purpose of the award is to investigate the interactions between progranulin insufficiency and the protein TDP-43 in the development of frontotemporal dementia (FTD), a major cause of early-onset dementia. The principal investigator at the University of Alabama at Birmingham (UAB) will use a mouse model to...
This National Institute on Aging (NIA) Project Grant award under the Aging Research Federal Grant Program (CFDA 93.866) in the amount of $787,095 provides funding for research to study the pathophysiological consequences of TAR-DNA binding protein 43 (TDP-43) pathology in oligodendrocytes (OLs) and its role in facilitating the spread of TDP-43 pathogenic species between glial and neuronal cells. The project, led by the Trustees of the University of Pennsylvania, aims to develop in vitro...
This $1,029,657 Project Grant awarded by the National Institute on Aging (NIA), part of the Aging Research Federal Grant Program (CFDA 93.866), supports research into the role of TDP-43 mislocalization, structure, and post-translational modifications in frontotemporal lobar degeneration (FTLD-TDP) and limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC). The award aims to investigate the molecular mechanisms underlying the region-specific accumulation of...
The National Institutes of Health's National Institute on Aging awarded the University of Wyoming a $4,510,756 project grant under the Aging Research program (CFDA 93.866) to investigate the impact of TAR DNA-binding protein 43 (TDP-43) loss on prefrontal neural activity and circuitry. The three-year award beginning September 2022 will support research using mouse models, human pluripotent stem cell-derived cortical neurons, and patient brain tissues to determine how TDP-43 loss leads to...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $242,290 will fund research to investigate the interaction between TDP-43 proteinopathy and hippocampal sclerosis in Alzheimer's disease. The award, with a term from September 2024 to June 2026, will support spatial transcriptomic analysis to better understand how novel TDP-43 protein species and hippocampal neuronal loss contribute to transcriptomic abnormalities in the hippocampus of...
This $602,015 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to identify the mechanisms underlying resilience to tau-induced synaptic dysfunction in Alzheimer's disease. The University of Alabama at Birmingham (UAB) will conduct research to determine if resilient patients have fewer pathogenic tau seeds in synaptic compartments or more resilient synapses, and identify the synaptic proteins and cellular pathways associated with tau seeding...
This $603,031 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Northwestern University supports a 1-year research study on the clinical, cellular, and pathological features of comorbid Alzheimer's disease and TDP-43 proteinopathies in elderly patients with amnestic dementia. The key objectives are to: 1) identify the shared versus distinct clinical, neuropsychological, and psychiatric characteristics of this condition; 2) determine the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is intended to support research characterizing novel mixed etiology dementia models with compromised TDP-43 function. The $210,310 award, which runs from June 2024 to October 2026, will enable The Johns Hopkins University to develop mouse models exhibiting Alzheimer's disease pathologies...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will investigate the synergistic relationship between the tau and TDP-43 proteins in the pathogenesis of Alzheimer's disease (AD). The $757,027 award, effective from January 1, 2025 to December 31, 2029, will utilize a C. elegans model to interrogate the mechanistic pathways underlying the interaction between tau and TDP-43 proteinopathies. The project aims to identify...
The federal Project Grant award R01NS136684, "BIOPHYSICAL AND PATHOPHYSIOLOGICAL STUDIES OF TDP-43/TAU INTERACTION," was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The $562,241 award, made on May 17, 2024, supports research at the University of Florida to investigate the interaction between the proteins TDP-43 and tau, and their role in age-related neurological conditions like Alzheimer's disease. The University of Florida is...

The University of Alabama at Birmingham (UAB) received a $816,750 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant, titled "POLY(ADP-RIBOSE)-DEPENDENT TDP-43 PATHOLOGY IN OXIDATIVE STRESS (R21)," aims to study the mechanisms by which the TDP-43 protein accumulates in the cytoplasm of neurons under oxidative stress conditions, which is a key pathological process in frontotemporal dementia (FTD) and other Alzheimer's-related dementias. The research will use biochemical, cell biological, and imaging techniques to investigate how the binding of poly(ADP-ribose) to TDP-43 facilitates its interaction with the nuclear export protein XPO1, leading to the mislocalization of TDP-43 from the nucleus to the cytoplasm. The findings from this 2-year project are expected to enhance the understanding of TDP-43 pathology in FTD, amyotrophic lateral sclerosis (ALS), and other neurodegenerative diseases involving TDP-43 accumulation.

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