The University of Alabama at Birmingham (UAB) has been awarded a $219,113 R21 grant from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The goal of this 2-year project is to investigate the mechanisms underlying synaptic resilience to tau pathology in Alzheimer's disease patients who maintain cognitive function despite the presence of Alzheimer's-related brain changes. Specifically, the research aims to identify synaptic proteins and cellular pathways associated with tau seeding and tau-induced synaptic dysfunction in Alzheimer's disease patients exhibiting resilience. The findings from this project are expected to open new avenues for developing therapeutic strategies that can modulate tau-induced synaptic dysfunction and preserve synapses in Alzheimer's disease.
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