This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $757,027 to the University of Washington to investigate the novel mechanisms of interaction between the tau and TDP-43 proteins in Alzheimer's disease (AD). The research aims to understand how the presence of both tau and TDP-43 pathologies can lead to more rapid cognitive decline and hippocampal atrophy in AD patients compared to tau pathology alone. The project will use C....
This $310,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by Texas Tech University Health Sciences Center (TTUHSC) to examine how alternative polyadenylation (APA) of mRNAs contributes to the development and progression of Alzheimer's disease (AD). The project has two main goals: 1) to identify APA genes and pathways associated with AD pathology using computational analysis of existing single-cell RNA-sequencing datasets, and 2)...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at Virginia Commonwealth University (VCU) to investigate the effect of the trans-synaptic spread of pathogenic tau protein in the hippocampus and its impact on vulnerable neuron subtypes in Alzheimer's disease (AD). The $408,638 award, effective from August 1, 2024 to July 31, 2026, will involve the use of adeno-associated viral vector transfection, immunofluorescence, and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the cell-type specific impacts of Alzheimer's disease (AD) pathology within the medial temporal lobe. The $103,304 award, effective August 1, 2024 through July 31, 2025, will utilize advanced viral tracing methods and microscopy imaging to identify and reconstruct 3D entorhinal cortex-CA1 neuron circuits that are susceptible to AD pathology propagation. After...
This $745,092 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the Rector & Visitors of the University of Virginia (UVA) to conduct research on the epitranscriptomic mechanisms underlying the pathogenesis of Alzheimer's disease (AD) and related tauopathies. The key goals of the project are to: 1) Decode the epitranscriptomic profiles impacted by tau pathology using m6A DART-seq, 2) Determine the role of RNA methylation in AD pathogenesis using 3D...
This $603,031 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Northwestern University supports a 1-year research study on the clinical, cellular, and pathological features of comorbid Alzheimer's disease and TDP-43 proteinopathies in elderly patients with amnestic dementia. The key objectives are to: 1) identify the shared versus distinct clinical, neuropsychological, and psychiatric characteristics of this condition; 2) determine the cellular...
This $146,922 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by The Johns Hopkins University to investigate physiological pathways that modulate tau protein homeostasis, with potential implications for Alzheimer's disease and related dementias. The key objectives are to: 1) Examine how the loss of the GDE2 protein affects the onset and progression of neurodegeneration, tau modifications, and aggregation in an animal model and...
This Project Grant award for $466,125, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to analyze the effects of Alzheimer's disease on subcellular transcriptome dynamics and mitonuclear coordination in neuronal soma and projections. The research, conducted by Harvard Medical School, will use a novel technique called Subcellular Timelapse-Seq (STL-Seq) to simultaneously quantify the kinetic rates of transcription, nuclear export, ribosome...
The National Institutes of Health's National Institute on Aging awarded the University of Wyoming a $4,510,756 project grant under the Aging Research program (CFDA 93.866) to investigate the impact of TAR DNA-binding protein 43 (TDP-43) loss on prefrontal neural activity and circuitry. The three-year award beginning September 2022 will support research using mouse models, human pluripotent stem cell-derived cortical neurons, and patient brain tissues to determine how TDP-43 loss leads to...
This federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to understand how advancing age contributes to the occurrence and progression of Alzheimer's disease (AD). The award, totaling $1,055,595.00 from July 2024 to April 2026, will support research at Colorado State University to determine how increasing endosome formation, a key cellular process, can decrease tau protein accumulation in neurons and influence cognition and AD pathology...