This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to The Trustees of Columbia University in the City of New York, Health Sciences Division, provides $749,030 in funding to investigate the mechanisms responsible for autophagy defects in neurons affected by Alzheimer's disease (AD). The primary objective is to understand the causal connection between dysregulation of neuronal calcium signaling and impaired autophagy, and how these processes...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,147,300.00 to Wayne State University to investigate the role of pathogenic tau protein in disrupting dendritic protein synthesis, which may contribute to synaptic dysfunction in Alzheimer's disease. The project aims to utilize tau pathology model mice and novel molecular tools to study how alterations in local protein synthesis in neuronal dendrites relate to the early synaptic...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Transchromix LLC in Chapel Hill, NC provides $994,436 to develop novel brain-penetrant drugs for treating Alzheimer's disease (AD). The researchers aim to further investigate a noncanonical, translation regulatory function of the histone methyltransferase G9A in AD pathogenesis, building on their prior discovery that G9A inhibition by the drug MS1262 can reverse AD-associated protein...
This federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), will support research to identify susceptible cell types within the medial temporal lobe (MTL) that are impacted by Alzheimer's disease (AD) pathology. The $103,304 award, spanning August 1, 2024 to July 31, 2025, will utilize advanced viral tracing and microscopy imaging techniques to characterize 3D neural circuits originating from entorhinal cortex (ENT) neurons projecting to the CA1...
This federal Project Grant award from the National Institutes of Health's National Institute on Aging (CFDA 93.866 - Aging Research) provides $169,560 to the Regents of the University of Michigan to conduct research on mapping and modeling inhibitory interneurons in Alzheimer's disease and related dementias. The overarching goals are to catalog disrupted interneuron gene expression, define inhibitory dysfunction in vitro using induced interneurons, and assess the impact of transplanting...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $833,173 to the University of North Carolina at Chapel Hill to optimize a potent and cell-active chemical probe targeting protein kinase CK2 for potential treatment of Alzheimer's disease. The research aims to develop an improved CK2 inhibitor that lacks broad antiproliferative activity, enabling confirmation of CK2's role in Alzheimer's disease pathways for the first time. The project will...
This Project Grant award, valued at $10,847,672 and funded by the National Institute on Aging's Aging Research program (CFDA 93.866), supports research on the mechanisms underlying cerebral amyloid angiopathy (CAA) and its relationship to Alzheimer's disease pathology. The primary awardee, J. David Gladstone Institutes, will conduct comprehensive studies using human postmortem brain samples, single-cell genomics, and mouse models to elucidate how microglia regulate the balance between vascular...
This federal Project Grant award, valued at $6,226,692.00 and funded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to investigate the role of neuronal hyperexcitability and proteostasis in the progression of Alzheimer's disease (AD). The study aims to track early electrophysiological changes in the locus coeruleus (LC) and hippocampus (HPC) as key brain regions impacted by the accumulation of beta-amyloid and tau proteins. The research seeks to understand...
This $784,596 Project Grant award, made under the National Institute on Aging's Aging Research program (CFDA 93.866), supports comprehensive proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease and tauopathy models at Northeastern University. The project aims to develop a state-of-the-art proteogenomic pipeline to globally profile disease-associated proteins with amino acid substitutions, alternative isoforms, post-translational modifications, and proteolytic...
This federal Project Grant award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, provides $816,661 to The Regents of the University of California, San Francisco to conduct research on the molecular and cellular mechanisms by which pathological tau protein drives neurodegeneration in Alzheimer's disease (AD) and related tauopathies. The project will leverage expertise in mass spectrometry-based proteomics and functional genomics to comprehensively map the impact of...