This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $551,986.00 to The Jackson Laboratory to develop an explainable unified AI strategy for efficient and robust integrative analysis of multi-omics data from heterogeneous longevity studies. The goal is to identify protective genetic variants associated with exceptional human longevity, which can inform therapeutic interventions to improve human health. The 2-year project aims to: 1) create...
The Washington University Office of Sponsored Research Services Division was awarded a $460,659 Project Grant from the National Institute on Aging's Aging Research program (CFDA 93.866) to develop novel artificial intelligence (AI) models for integrating and interpreting multi-omics datasets related to exceptional longevity. The project aims to (1) develop unbiased and semi-guided graph neural network models to infer core signaling pathways associated with exceptional lifespan, and (2) create...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $2,415,848 to the University of Virginia to conduct research on understanding the role of essential genes in the aging process across different organisms. The key objectives are to: Screen conserved essential genes in C. elegans to identify those that influence lifespan, Analyze genome-wide mRNA expression changes in long-lived strains to elucidate the genetic mechanisms underlying lifespan...
This federal Project Grant award of $105,952 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by Weill Medical College of Cornell University to identify and characterize clonal expansions in aging and aging-related diseases. The key objectives are to: (1) develop tools to identify candidate somatic variants at scale from publicly available data, and (2) apply novel technologies that map genotype to epigenetic phenotype in single cells, enabling analysis of...
This $312,900 federal project grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research to identify the genetic basis of longevity and the response to life-extending compound interventions in the model organism Caenorhabditis elegans. The University of Oregon will use unique genetic mapping approaches and a novel genomic engineering technique to analyze natural isolates of C. elegans that exhibit exceptional longevity. This work aims to uncover...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $434,500 to the Research Foundation of the City University of New York (RFCUNY) to investigate the dopaminergic mechanisms underlying familiarity bias and memory interference in aging. The project aims to determine how dysfunction in dopamine neurons projecting to the lateral entorhinal cortex (LEC) affects memory interference in aged mice, using techniques like fiber photometry, optogenetics,...
Duke University received a $1,019,484.58 Project Grant award from the National Institutes of Health's National Institute on Aging under the Aging Research program (CFDA 93.866) for the period September 1, 2021 through May 31, 2022. The award will support research using the nematode C. elegans as a model organism to study aging-associated neurodegeneration at the molecular level, with the goals of uncovering novel mechanisms underlying this process and establishing C. elegans neurons as a...
This three-year project grant from the National Institutes of Health's National Institute on Aging, titled "Aging Research" under the CFDA number 93.866, provides $1,797,870 to Stony Brook University to investigate the mechanisms by which aging impacts the risks of Alzheimer's and related dementias. Specifically, the awardee will test the hypothesis that age and neurodegenerative protein pathology synergize to activate retrotransposons and endogenous retroviruses, mobile genetic...
The National Institute on Aging (NIA) awarded a $802,034 Project Grant under the Aging Research program (CFDA 93.866) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The grant will fund a 5-year project to develop a comprehensive "Multimodal, Multiscale and Multistage Systems Biology (M3SB) Infrastructure for Precision Medicine in Alzheimer's Disease and Longevity." The project aims to conduct multi-modal analyses of genetics, multi-omics data,...
The National Institute on Aging (NIA) awarded a $431,132 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Albert Einstein College of Medicine to conduct research on the "Loss of the Y Chromosome and its Implications in Aging". The research aims to explore the genetic factors and mechanisms underlying the relationship between the loss of the Y chromosome (LOY) and the aging process, with the goal of developing a better understanding of age-related...